Extending the viability of human precision-cut intestinal slice model for drug metabolism studies

Human Precision-cut intestinal slices (hPCIS) are used to study intestinal physiology, pathophysiology, drug efficacy, toxicology, kinetics, and metabolism. However, the use of this ex vivo model is restricted to approximately a 24 h timeframe because of declining viability of the hPCIS during tradi...

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Detalles Bibliográficos
Autores principales: Biel, C., Martinec, O., Sibering, B., van Summeren, K., Wessels, A. M. A., Touw, D. J., de Jong, K. P., de Meijer, V. E., Faber, K. N., Klooster, J. P. ten, de Graaf, I. A. M., Olinga, P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
In Vitro Systems
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095520/
https://www.ncbi.nlm.nih.gov/pubmed/35428896
http://dx.doi.org/10.1007/s00204-022-03295-1

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