Microdosing as a Potential Tool to Enhance Clinical Development of Novel Antibiotics: A Tissue and Plasma PK Feasibility Study with Ciprofloxacin

BACKGROUND AND OBJECTIVE: In microdose studies, drug pharmacokinetics is measured in humans after administration of subtherapeutic doses. While previous microdose studies focused primarily on plasma pharmacokinetics, we set out to evaluate the feasibility of microdosing for a pharmacokinetic assessm...

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Detalles Bibliográficos
Autores principales: Oesterreicher, Zoe, Eberl, Sabine, Wulkersdorfer, Beatrix, Matzneller, Peter, Eder, Claudia, van Duijn, Esther, Vaes, Wouter H. J., Reiter, Birgit, Stimpfl, Thomas, Jäger, Walter, Nussbaumer-Proell, Alina, Marhofer, Daniela, Marhofer, Peter, Langer, Oliver, Zeitlinger, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095552/
https://www.ncbi.nlm.nih.gov/pubmed/34997559
http://dx.doi.org/10.1007/s40262-021-01091-1

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