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“De-Shrinking” EBEs: The Solution for Bayesian Therapeutic Drug Monitoring
BACKGROUND: Therapeutic drug monitoring (TDM) aims at individualising a dosage regimen and is increasingly being performed by estimating individual pharmacokinetic parameters via empirical Bayes estimates (EBEs). However, EBEs suffer from shrinkage that makes them biased. This bias is a weakness for...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer International Publishing
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095561/ https://www.ncbi.nlm.nih.gov/pubmed/35119624 http://dx.doi.org/10.1007/s40262-021-01105-y |