TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC

TOPK/PBK (T-LAK Cell-Originated Protein Kinase) is a serine/threonine kinase that is highly expressed in a variety of human tumors and is associated with poor prognosis in many types of human malignancies. Its activation mechanism is not yet fully understood. A bidirectional signal transduced betwee...

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Detalles Bibliográficos
Autores principales: Sun, Huimin, Zheng, Jianzhong, Xiao, Juanjuan, Yue, Juntao, Shi, Zhiyuan, Xuan, Zuodong, Chen, Chen, Zhao, Yue, Tang, Wenbin, Ye, Shaopei, Li, Jinxin, Deng, Qiumin, Zhang, Lei, Zhu, Feng, Shao, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095598/
https://www.ncbi.nlm.nih.gov/pubmed/35546143
http://dx.doi.org/10.1038/s41419-022-04909-3

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