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RyR2/IRBIT regulates insulin gene transcript, insulin content, and secretion in the insulinoma cell line INS-1

The role of ER Ca(2+) release via ryanodine receptors (RyR) in pancreatic β-cell function is not well defined. Deletion of RyR2 from the rat insulinoma INS-1 (RyR2(KO)) enhanced IP(3) receptor activity stimulated by 7.5 mM glucose, coincident with reduced levels of the protein IP(3) Receptor Binding...

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Detalles Bibliográficos
Autores principales:	Harvey, Kyle E., LaVigne, Emily K., Dar, Mohd Saleem, Salyer, Amy E., Pratt, Evan P. S., Sample, Paxton A., Aryal, Uma K., Gowher, Humaira, Hockerman, Gregory H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095623/ https://www.ncbi.nlm.nih.gov/pubmed/35562179 http://dx.doi.org/10.1038/s41598-022-11276-8

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