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Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes
The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095642/ https://www.ncbi.nlm.nih.gov/pubmed/35545657 http://dx.doi.org/10.1038/s41746-022-00606-9 |
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author | Dwibedi, Chinmay Mellergård, Emelia Gyllensten, Amaru Cuba Nilsson, Kristoffer Axelsson, Annika S. Bäckman, Malin Sahlgren, Magnus Friend, Stephen H. Persson, Sofie Franzén, Stefan Abrahamsson, Birgitta Carlsson, Katarina Steen Rosengren, Anders H. |
author_facet | Dwibedi, Chinmay Mellergård, Emelia Gyllensten, Amaru Cuba Nilsson, Kristoffer Axelsson, Annika S. Bäckman, Malin Sahlgren, Magnus Friend, Stephen H. Persson, Sofie Franzén, Stefan Abrahamsson, Birgitta Carlsson, Katarina Steen Rosengren, Anders H. |
author_sort | Dwibedi, Chinmay |
collection | PubMed |
description | The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool had reduced blood glucose, both compared with randomized and matched controls (involving 158 and 204 users, respectively), as well as improved systolic blood pressure, body weight and insulin resistance. The improvement was sustained during the entire follow-up (average 730 days). A pathophysiological subgroup of obese insulin-resistant individuals had a pronounced glycemic response, enabling identification of those who would benefit in particular from lifestyle treatment. Natural language processing showed that the metabolic improvement was coupled with the self-reflective element of the tool. The treatment is cost-saving because of improved risk factor control for cardiovascular complications. The findings open an avenue for self-managed lifestyle treatment with long-term metabolic efficacy that is cost-saving and can reach large numbers of people. |
format | Online Article Text |
id | pubmed-9095642 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-90956422022-05-13 Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes Dwibedi, Chinmay Mellergård, Emelia Gyllensten, Amaru Cuba Nilsson, Kristoffer Axelsson, Annika S. Bäckman, Malin Sahlgren, Magnus Friend, Stephen H. Persson, Sofie Franzén, Stefan Abrahamsson, Birgitta Carlsson, Katarina Steen Rosengren, Anders H. NPJ Digit Med Article The lack of effective, scalable solutions for lifestyle treatment is a global clinical problem, causing severe morbidity and mortality. We developed a method for lifestyle treatment that promotes self-reflection and iterative behavioral change, provided as a digital tool, and evaluated its effect in 370 patients with type 2 diabetes (ClinicalTrials.gov identifier: NCT04691973). Users of the tool had reduced blood glucose, both compared with randomized and matched controls (involving 158 and 204 users, respectively), as well as improved systolic blood pressure, body weight and insulin resistance. The improvement was sustained during the entire follow-up (average 730 days). A pathophysiological subgroup of obese insulin-resistant individuals had a pronounced glycemic response, enabling identification of those who would benefit in particular from lifestyle treatment. Natural language processing showed that the metabolic improvement was coupled with the self-reflective element of the tool. The treatment is cost-saving because of improved risk factor control for cardiovascular complications. The findings open an avenue for self-managed lifestyle treatment with long-term metabolic efficacy that is cost-saving and can reach large numbers of people. Nature Publishing Group UK 2022-05-11 /pmc/articles/PMC9095642/ /pubmed/35545657 http://dx.doi.org/10.1038/s41746-022-00606-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Dwibedi, Chinmay Mellergård, Emelia Gyllensten, Amaru Cuba Nilsson, Kristoffer Axelsson, Annika S. Bäckman, Malin Sahlgren, Magnus Friend, Stephen H. Persson, Sofie Franzén, Stefan Abrahamsson, Birgitta Carlsson, Katarina Steen Rosengren, Anders H. Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title | Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title_full | Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title_fullStr | Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title_full_unstemmed | Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title_short | Effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
title_sort | effect of self-managed lifestyle treatment on glycemic control in patients with type 2 diabetes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095642/ https://www.ncbi.nlm.nih.gov/pubmed/35545657 http://dx.doi.org/10.1038/s41746-022-00606-9 |
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