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TMEM16 scramblases thin the membrane to enable lipid scrambling

TMEM16 scramblases dissipate the plasma membrane lipid asymmetry to activate multiple eukaryotic cellular pathways. Scrambling was proposed to occur with lipid headgroups moving between leaflets through a membrane-spanning hydrophilic groove. Direct information on lipid-groove interactions is lackin...

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Detalles Bibliográficos
Autores principales:	Falzone, Maria E., Feng, Zhang, Alvarenga, Omar E., Pan, Yangang, Lee, ByoungCheol, Cheng, Xiaolu, Fortea, Eva, Scheuring, Simon, Accardi, Alessio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095706/ https://www.ncbi.nlm.nih.gov/pubmed/35562175 http://dx.doi.org/10.1038/s41467-022-30300-z

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