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Septic shock in a woman with a hydatidiform mole: A case report

Hydatidiform moles can be fatal because of the risk of massive bleeding or thyroid storm; however, they rarely occur concomitantly with sepsis. We present herein the case of a woman with a hydatidiform mole with septic shock. A 30-year-old multiparous woman with Basedow's disease presented with...

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Autores principales: Yoshimoto, Yuki, Murata, Tsuyoshi, Machida, Moeko, Nozawa, Yoshihiro, Nakamura, Soichi, Yamauchi, Ryuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095736/
https://www.ncbi.nlm.nih.gov/pubmed/35574176
http://dx.doi.org/10.1016/j.crwh.2022.e00417
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author Yoshimoto, Yuki
Murata, Tsuyoshi
Machida, Moeko
Nozawa, Yoshihiro
Nakamura, Soichi
Yamauchi, Ryuji
author_facet Yoshimoto, Yuki
Murata, Tsuyoshi
Machida, Moeko
Nozawa, Yoshihiro
Nakamura, Soichi
Yamauchi, Ryuji
author_sort Yoshimoto, Yuki
collection PubMed
description Hydatidiform moles can be fatal because of the risk of massive bleeding or thyroid storm; however, they rarely occur concomitantly with sepsis. We present herein the case of a woman with a hydatidiform mole with septic shock. A 30-year-old multiparous woman with Basedow's disease presented with fever, amenorrhea, and vaginal bleeding. Transvaginal ultrasonography revealed an enlarged uterus with an intrauterine vesicular mass (74.3 × 93.0 mm). Human chorionic gonadotropin level was 994,000 mIU/mL. C-reactive protein was elevated, and blood cultures were positive (gram-negative rods), indicating infection. After administering antibiotics (tazobactam and piperacillin), blood pressure suddenly decreased (69/45 mmHg), requiring stabilization with noradrenaline and albumin. The uterine contents were naturally expelled, followed by dilatation and curettage after her vital signs and general condition gradually improved. The pathological diagnosis was a complete hydatidiform mole. Culture of the intrauterine contents revealed Escherichia coli, leading to the potentially fatal diagnosis of septic shock associated with a hydatidiform mole.
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spelling pubmed-90957362022-05-13 Septic shock in a woman with a hydatidiform mole: A case report Yoshimoto, Yuki Murata, Tsuyoshi Machida, Moeko Nozawa, Yoshihiro Nakamura, Soichi Yamauchi, Ryuji Case Rep Womens Health Article Hydatidiform moles can be fatal because of the risk of massive bleeding or thyroid storm; however, they rarely occur concomitantly with sepsis. We present herein the case of a woman with a hydatidiform mole with septic shock. A 30-year-old multiparous woman with Basedow's disease presented with fever, amenorrhea, and vaginal bleeding. Transvaginal ultrasonography revealed an enlarged uterus with an intrauterine vesicular mass (74.3 × 93.0 mm). Human chorionic gonadotropin level was 994,000 mIU/mL. C-reactive protein was elevated, and blood cultures were positive (gram-negative rods), indicating infection. After administering antibiotics (tazobactam and piperacillin), blood pressure suddenly decreased (69/45 mmHg), requiring stabilization with noradrenaline and albumin. The uterine contents were naturally expelled, followed by dilatation and curettage after her vital signs and general condition gradually improved. The pathological diagnosis was a complete hydatidiform mole. Culture of the intrauterine contents revealed Escherichia coli, leading to the potentially fatal diagnosis of septic shock associated with a hydatidiform mole. Elsevier 2022-04-27 /pmc/articles/PMC9095736/ /pubmed/35574176 http://dx.doi.org/10.1016/j.crwh.2022.e00417 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Yoshimoto, Yuki
Murata, Tsuyoshi
Machida, Moeko
Nozawa, Yoshihiro
Nakamura, Soichi
Yamauchi, Ryuji
Septic shock in a woman with a hydatidiform mole: A case report
title Septic shock in a woman with a hydatidiform mole: A case report
title_full Septic shock in a woman with a hydatidiform mole: A case report
title_fullStr Septic shock in a woman with a hydatidiform mole: A case report
title_full_unstemmed Septic shock in a woman with a hydatidiform mole: A case report
title_short Septic shock in a woman with a hydatidiform mole: A case report
title_sort septic shock in a woman with a hydatidiform mole: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095736/
https://www.ncbi.nlm.nih.gov/pubmed/35574176
http://dx.doi.org/10.1016/j.crwh.2022.e00417
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