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Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease

BACKGROUND: Individuals with a higher lifelong cardiorespiratory fitness show better vascular health with aging. Studies on fitness-related effects on endothelial function either analyzed samples with a narrow age-range or incompletely assessed endothelial responsiveness. This study aims to assess t...

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Autores principales: Königstein, Karsten, Wagner, Jonathan, Infanger, Denis, Knaier, Raphael, Nève, Gilles, Klenk, Christopher, Carrard, Justin, Hinrichs, Timo, Schmidt-Trucksäss, Arno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095821/
https://www.ncbi.nlm.nih.gov/pubmed/35571175
http://dx.doi.org/10.3389/fcvm.2022.870847
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author Königstein, Karsten
Wagner, Jonathan
Infanger, Denis
Knaier, Raphael
Nève, Gilles
Klenk, Christopher
Carrard, Justin
Hinrichs, Timo
Schmidt-Trucksäss, Arno
author_facet Königstein, Karsten
Wagner, Jonathan
Infanger, Denis
Knaier, Raphael
Nève, Gilles
Klenk, Christopher
Carrard, Justin
Hinrichs, Timo
Schmidt-Trucksäss, Arno
author_sort Königstein, Karsten
collection PubMed
description BACKGROUND: Individuals with a higher lifelong cardiorespiratory fitness show better vascular health with aging. Studies on fitness-related effects on endothelial function either analyzed samples with a narrow age-range or incompletely assessed endothelial responsiveness. This study aims to assess the impact of cardiorespiratory fitness on the association of brachial-arterial flow-mediated vasodilation (FMD) and low flow-mediated vasoconstriction (L-FMC) with age in healthy adults and patients with cardiovascular diseases. METHODS: FMD, L-FMC and [Formula: see text] O(2)peak were prospectively measured in a population-based sample including 360 healthy adults and 99 patients with cardiovascular disease of European descend. Non-linear models were applied to assess [Formula: see text] O(2)peak-associated variations in age-related differences of endothelial function independent of classical cardiovascular risk factors. RESULTS: FMD was negatively associated with age in healthy adults (adjusted R(2) = 0.27, partial R(2) = 0.07, p < 0.001) and in cardiovascular patients (adjusted R(2) = 0.29, partial R(2) = 0.05, p = 002). L-FMC showed no association with age. In models predicting the change of FMD with higher age, [Formula: see text] O(2)peak accounted for 2.8% of variation in FMD (χ(2)(5) = 5.37, p = 0.372, s = 1.43). Thereby, [Formula: see text] O(2)peak-stratified changes of FMD started to fan out at around 30 years of age in women and 50 years of age in men, with 7–12% lower values at old age with [Formula: see text] O(2)peak ≤3rd percentile compared to [Formula: see text] O(2)peak ≥97th percentile) in both, the healthy sample and in cardiovascular patients. CONCLUSION: The statistical effect of cardiorespiratory fitness on the association of FMD with age independent of classical cardiovascular risk factors was small in both, healthy aging adults as well as patients with cardiovascular diseases. Its clinical significance should be assessed further.
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spelling pubmed-90958212022-05-13 Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease Königstein, Karsten Wagner, Jonathan Infanger, Denis Knaier, Raphael Nève, Gilles Klenk, Christopher Carrard, Justin Hinrichs, Timo Schmidt-Trucksäss, Arno Front Cardiovasc Med Cardiovascular Medicine BACKGROUND: Individuals with a higher lifelong cardiorespiratory fitness show better vascular health with aging. Studies on fitness-related effects on endothelial function either analyzed samples with a narrow age-range or incompletely assessed endothelial responsiveness. This study aims to assess the impact of cardiorespiratory fitness on the association of brachial-arterial flow-mediated vasodilation (FMD) and low flow-mediated vasoconstriction (L-FMC) with age in healthy adults and patients with cardiovascular diseases. METHODS: FMD, L-FMC and [Formula: see text] O(2)peak were prospectively measured in a population-based sample including 360 healthy adults and 99 patients with cardiovascular disease of European descend. Non-linear models were applied to assess [Formula: see text] O(2)peak-associated variations in age-related differences of endothelial function independent of classical cardiovascular risk factors. RESULTS: FMD was negatively associated with age in healthy adults (adjusted R(2) = 0.27, partial R(2) = 0.07, p < 0.001) and in cardiovascular patients (adjusted R(2) = 0.29, partial R(2) = 0.05, p = 002). L-FMC showed no association with age. In models predicting the change of FMD with higher age, [Formula: see text] O(2)peak accounted for 2.8% of variation in FMD (χ(2)(5) = 5.37, p = 0.372, s = 1.43). Thereby, [Formula: see text] O(2)peak-stratified changes of FMD started to fan out at around 30 years of age in women and 50 years of age in men, with 7–12% lower values at old age with [Formula: see text] O(2)peak ≤3rd percentile compared to [Formula: see text] O(2)peak ≥97th percentile) in both, the healthy sample and in cardiovascular patients. CONCLUSION: The statistical effect of cardiorespiratory fitness on the association of FMD with age independent of classical cardiovascular risk factors was small in both, healthy aging adults as well as patients with cardiovascular diseases. Its clinical significance should be assessed further. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9095821/ /pubmed/35571175 http://dx.doi.org/10.3389/fcvm.2022.870847 Text en Copyright © 2022 Königstein, Wagner, Infanger, Knaier, Nève, Klenk, Carrard, Hinrichs and Schmidt-Trucksäss. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Königstein, Karsten
Wagner, Jonathan
Infanger, Denis
Knaier, Raphael
Nève, Gilles
Klenk, Christopher
Carrard, Justin
Hinrichs, Timo
Schmidt-Trucksäss, Arno
Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title_full Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title_fullStr Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title_full_unstemmed Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title_short Cardiorespiratory Fitness and Endothelial Function in Aging Healthy Subjects and Patients With Cardiovascular Disease
title_sort cardiorespiratory fitness and endothelial function in aging healthy subjects and patients with cardiovascular disease
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095821/
https://www.ncbi.nlm.nih.gov/pubmed/35571175
http://dx.doi.org/10.3389/fcvm.2022.870847
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