The Cellular Senescence Factor Extracellular HMGB1 Directly Inhibits Oligodendrocyte Progenitor Cell Differentiation and Impairs CNS Remyelination

HMGB1 is a highly conserved, ubiquitous protein in eukaryotic cells. HMGB1 is normally localized to the nucleus, where it acts as a chromatin associated non-histone binding protein. In contrast, extracellular HMGB1 is an alarmin released by stressed cells to act as a danger associated molecular patt...

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Detalles Bibliográficos
Autores principales: Rouillard, Megan E., Hu, Jingwen, Sutter, Pearl A., Kim, Hee Won, Huang, Jeffrey K., Crocker, Stephen J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095917/
https://www.ncbi.nlm.nih.gov/pubmed/35573828
http://dx.doi.org/10.3389/fncel.2022.833186

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