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Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke

Stroke is the world’s second major cause of adult death and disability, resulting in the destruction of brain tissue and long-term neurological impairment; induction of neuronal plasticity can promote recovery after stroke. C–C chemokine receptor 5 (CCR5) can direct leukocyte migration and localizat...

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Autores principales: Feng, Yi-Qi, Xu, Zhen-Zhen, Wang, Yan-Ting, Xiong, Yue, Xie, Wanli, He, Yu-Yao, Chen, Lu, Liu, Guo-Yang, Li, Xia, Liu, Jie, Wu, Qingping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095921/
https://www.ncbi.nlm.nih.gov/pubmed/35573839
http://dx.doi.org/10.3389/fncel.2022.876342
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author Feng, Yi-Qi
Xu, Zhen-Zhen
Wang, Yan-Ting
Xiong, Yue
Xie, Wanli
He, Yu-Yao
Chen, Lu
Liu, Guo-Yang
Li, Xia
Liu, Jie
Wu, Qingping
author_facet Feng, Yi-Qi
Xu, Zhen-Zhen
Wang, Yan-Ting
Xiong, Yue
Xie, Wanli
He, Yu-Yao
Chen, Lu
Liu, Guo-Yang
Li, Xia
Liu, Jie
Wu, Qingping
author_sort Feng, Yi-Qi
collection PubMed
description Stroke is the world’s second major cause of adult death and disability, resulting in the destruction of brain tissue and long-term neurological impairment; induction of neuronal plasticity can promote recovery after stroke. C–C chemokine receptor 5 (CCR5) can direct leukocyte migration and localization and is a co-receptor that can mediate human immunodeficiency virus (HIV) entry into cells. Its role in HIV infection and immune response has been extensively studied. Furthermore, CCR5 is widely expressed in the central nervous system (CNS), is engaged in various physiological activities such as brain development, neuronal differentiation, communication, survival, and learning and memory capabilities, and is also involved in the development of numerous neurological diseases. CCR5 is differentially upregulated in neurons after stroke, and the inhibition of CCR5 in specific regions of the brain promotes motor and cognitive recovery. The mechanism by which CCR5 acts as a therapeutic target to promote neurorehabilitation after stroke has rarely been systematically reported yet. Thus, this review aims to discuss the function of CCR5 in the CNS and the mechanism of its effect on post-stroke recovery by regulating neuroplasticity and the inflammatory response to provide an effective basis for clinical rehabilitation after stroke.
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spelling pubmed-90959212022-05-13 Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke Feng, Yi-Qi Xu, Zhen-Zhen Wang, Yan-Ting Xiong, Yue Xie, Wanli He, Yu-Yao Chen, Lu Liu, Guo-Yang Li, Xia Liu, Jie Wu, Qingping Front Cell Neurosci Neuroscience Stroke is the world’s second major cause of adult death and disability, resulting in the destruction of brain tissue and long-term neurological impairment; induction of neuronal plasticity can promote recovery after stroke. C–C chemokine receptor 5 (CCR5) can direct leukocyte migration and localization and is a co-receptor that can mediate human immunodeficiency virus (HIV) entry into cells. Its role in HIV infection and immune response has been extensively studied. Furthermore, CCR5 is widely expressed in the central nervous system (CNS), is engaged in various physiological activities such as brain development, neuronal differentiation, communication, survival, and learning and memory capabilities, and is also involved in the development of numerous neurological diseases. CCR5 is differentially upregulated in neurons after stroke, and the inhibition of CCR5 in specific regions of the brain promotes motor and cognitive recovery. The mechanism by which CCR5 acts as a therapeutic target to promote neurorehabilitation after stroke has rarely been systematically reported yet. Thus, this review aims to discuss the function of CCR5 in the CNS and the mechanism of its effect on post-stroke recovery by regulating neuroplasticity and the inflammatory response to provide an effective basis for clinical rehabilitation after stroke. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9095921/ /pubmed/35573839 http://dx.doi.org/10.3389/fncel.2022.876342 Text en Copyright © 2022 Feng, Xu, Wang, Xiong, Xie, He, Chen, Liu, Li, Liu and Wu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Feng, Yi-Qi
Xu, Zhen-Zhen
Wang, Yan-Ting
Xiong, Yue
Xie, Wanli
He, Yu-Yao
Chen, Lu
Liu, Guo-Yang
Li, Xia
Liu, Jie
Wu, Qingping
Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title_full Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title_fullStr Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title_full_unstemmed Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title_short Targeting C–C Chemokine Receptor 5: Key to Opening the Neurorehabilitation Window After Ischemic Stroke
title_sort targeting c–c chemokine receptor 5: key to opening the neurorehabilitation window after ischemic stroke
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095921/
https://www.ncbi.nlm.nih.gov/pubmed/35573839
http://dx.doi.org/10.3389/fncel.2022.876342
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