The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice

Previous studies have shown that B.1.351 and other variants have extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in a population. However, no evidence of natural transmission of SARS-CoV-2...

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Autores principales: Zhang, Cheng, Cui, Huan, Li, Entao, Guo, Zhendong, Wang, Tiecheng, Yan, Fang, Liu, Lina, Li, Yuanguo, Chen, Di, Meng, Keyin, Li, Nan, Qin, Chengfeng, Liu, Juxiang, Gao, Yuwei, Zhang, Chunmao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095975/
https://www.ncbi.nlm.nih.gov/pubmed/35572504
http://dx.doi.org/10.3389/fimmu.2022.869809
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author Zhang, Cheng
Cui, Huan
Li, Entao
Guo, Zhendong
Wang, Tiecheng
Yan, Fang
Liu, Lina
Li, Yuanguo
Chen, Di
Meng, Keyin
Li, Nan
Qin, Chengfeng
Liu, Juxiang
Gao, Yuwei
Zhang, Chunmao
author_facet Zhang, Cheng
Cui, Huan
Li, Entao
Guo, Zhendong
Wang, Tiecheng
Yan, Fang
Liu, Lina
Li, Yuanguo
Chen, Di
Meng, Keyin
Li, Nan
Qin, Chengfeng
Liu, Juxiang
Gao, Yuwei
Zhang, Chunmao
author_sort Zhang, Cheng
collection PubMed
description Previous studies have shown that B.1.351 and other variants have extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in a population. However, no evidence of natural transmission of SARS-CoV-2 in wild mice has been documented to date. Here, we evaluated the replication and contact transmission of the B.1.351 variant in mice and rats. The B.1.351 variant could infect and replicate efficiently in the airways of mice and rats. Furthermore, the B.1.351 variant could not be transmitted in BALB/c or C57BL/6 mice but could be transmitted with moderate efficiency in rats by direct contact. Additionally, the B.1.351 variant did not transmit from inoculated Syrian hamsters to BALB/c mice. Moreover, the mouse-adapted SARS-CoV-2 strain C57MA14 did not transmit in mice. In summary, the risk of B.1.351 variant transmission in mice is extremely low, but the transmission risk in rats should not be neglected. We should pay more attention to the potential natural transmission of SARS-CoV-2 variants in rats and their possible spillback to humans.
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spelling pubmed-90959752022-05-13 The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice Zhang, Cheng Cui, Huan Li, Entao Guo, Zhendong Wang, Tiecheng Yan, Fang Liu, Lina Li, Yuanguo Chen, Di Meng, Keyin Li, Nan Qin, Chengfeng Liu, Juxiang Gao, Yuwei Zhang, Chunmao Front Immunol Immunology Previous studies have shown that B.1.351 and other variants have extended the host range of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to mice. Sustained transmission is a prerequisite for viral maintenance in a population. However, no evidence of natural transmission of SARS-CoV-2 in wild mice has been documented to date. Here, we evaluated the replication and contact transmission of the B.1.351 variant in mice and rats. The B.1.351 variant could infect and replicate efficiently in the airways of mice and rats. Furthermore, the B.1.351 variant could not be transmitted in BALB/c or C57BL/6 mice but could be transmitted with moderate efficiency in rats by direct contact. Additionally, the B.1.351 variant did not transmit from inoculated Syrian hamsters to BALB/c mice. Moreover, the mouse-adapted SARS-CoV-2 strain C57MA14 did not transmit in mice. In summary, the risk of B.1.351 variant transmission in mice is extremely low, but the transmission risk in rats should not be neglected. We should pay more attention to the potential natural transmission of SARS-CoV-2 variants in rats and their possible spillback to humans. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9095975/ /pubmed/35572504 http://dx.doi.org/10.3389/fimmu.2022.869809 Text en Copyright © 2022 Zhang, Cui, Li, Guo, Wang, Yan, Liu, Li, Chen, Meng, Li, Qin, Liu, Gao and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Cheng
Cui, Huan
Li, Entao
Guo, Zhendong
Wang, Tiecheng
Yan, Fang
Liu, Lina
Li, Yuanguo
Chen, Di
Meng, Keyin
Li, Nan
Qin, Chengfeng
Liu, Juxiang
Gao, Yuwei
Zhang, Chunmao
The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title_full The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title_fullStr The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title_full_unstemmed The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title_short The SARS-CoV-2 B.1.351 Variant Can Transmit in Rats But Not in Mice
title_sort sars-cov-2 b.1.351 variant can transmit in rats but not in mice
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095975/
https://www.ncbi.nlm.nih.gov/pubmed/35572504
http://dx.doi.org/10.3389/fimmu.2022.869809
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