Optimization of eIF4E-Binding Peptide Pep8 to Disrupt the RBM38-eIF4E Complex for Induction of p53 and Tumor Suppression

Interaction of RNA-binding protein RBM38 with eIF4E on p53 mRNA is known to suppress p53 mRNA translation, which can be disrupted by an 8-amino acid peptide (Pep8-YPYAASPA) derived from RBM38, leading to induction of p53 and tumor suppression. Here, we rationally designed multiple Pep8 derivatives a...

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Detalles Bibliográficos
Autores principales: Lucchesi, Christopher A., Zhang, Jin, Vasilatis, Demitria M., Yip, Elizabeth, Chen, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095979/
https://www.ncbi.nlm.nih.gov/pubmed/35574389
http://dx.doi.org/10.3389/fonc.2022.893062

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9095979/
https://www.ncbi.nlm.nih.gov/pubmed/35574389
http://dx.doi.org/10.3389/fonc.2022.893062

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