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The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer

OBJECTIVE: This study was to explore the difference and significance of parietal pleura invasion and rib invasion in pathological T classification with non-small cell lung cancer. METHODS: A total of 8681 patients after lung resection were selected to perform analyses. Multivariable Cox analysis was...

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Autores principales: Wu, Lei-Lei, Li, Chong-Wu, Li, Kun, Qiu, Li-Hong, Xu, Shu-Quan, Lin, Wei-Kang, Ma, Guo-Wei, Li, Zhi-Xin, Xie, Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096107/
https://www.ncbi.nlm.nih.gov/pubmed/35574398
http://dx.doi.org/10.3389/fonc.2022.878482
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author Wu, Lei-Lei
Li, Chong-Wu
Li, Kun
Qiu, Li-Hong
Xu, Shu-Quan
Lin, Wei-Kang
Ma, Guo-Wei
Li, Zhi-Xin
Xie, Dong
author_facet Wu, Lei-Lei
Li, Chong-Wu
Li, Kun
Qiu, Li-Hong
Xu, Shu-Quan
Lin, Wei-Kang
Ma, Guo-Wei
Li, Zhi-Xin
Xie, Dong
author_sort Wu, Lei-Lei
collection PubMed
description OBJECTIVE: This study was to explore the difference and significance of parietal pleura invasion and rib invasion in pathological T classification with non-small cell lung cancer. METHODS: A total of 8681 patients after lung resection were selected to perform analyses. Multivariable Cox analysis was used to identify the mortality differences in patients between parietal pleura invasion and rib invasion. Eligible patients with chest wall invasion were re-categorized according to the prognosis. Cancer-specific survival curves for different pathological T (pT) classifications were presented. RESULTS: There were 466 patients considered parietal pleura invasion, and 237 patients served as rib invasion. Cases with rib invasion had poorer survival than those with the invasion of parietal pleura (adjusted hazard ratio [HR]= 1.627, P =0.004). In the cohort for parietal pleura invasion, patients with tumor size ≤5cm reached more satisfactory survival outcomes than patients with tumor size >5cm (unadjusted HR =1.598, P =0.006). However, there was no predictive difference in the cohort of rib invasion. The results of the multivariable analysis revealed that the mortality with parietal pleura invasion plus tumor size ≤5cm were similar to patients with classification pT3 (P =0.761), and patients for parietal pleura invasion plus tumor size >5cm and pT4 had no stratified survival outcome (P =0.809). Patients identified as rib invasion had a poorer prognosis than patients for pT4 (P =0.037). CONCLUSIONS: Rib invasion has a poorer prognosis than pT4. Patients with parietal pleura invasion and tumor size with 5.1-7.0cm could be appropriately up-classified from pT3 to pT4.
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spelling pubmed-90961072022-05-13 The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer Wu, Lei-Lei Li, Chong-Wu Li, Kun Qiu, Li-Hong Xu, Shu-Quan Lin, Wei-Kang Ma, Guo-Wei Li, Zhi-Xin Xie, Dong Front Oncol Oncology OBJECTIVE: This study was to explore the difference and significance of parietal pleura invasion and rib invasion in pathological T classification with non-small cell lung cancer. METHODS: A total of 8681 patients after lung resection were selected to perform analyses. Multivariable Cox analysis was used to identify the mortality differences in patients between parietal pleura invasion and rib invasion. Eligible patients with chest wall invasion were re-categorized according to the prognosis. Cancer-specific survival curves for different pathological T (pT) classifications were presented. RESULTS: There were 466 patients considered parietal pleura invasion, and 237 patients served as rib invasion. Cases with rib invasion had poorer survival than those with the invasion of parietal pleura (adjusted hazard ratio [HR]= 1.627, P =0.004). In the cohort for parietal pleura invasion, patients with tumor size ≤5cm reached more satisfactory survival outcomes than patients with tumor size >5cm (unadjusted HR =1.598, P =0.006). However, there was no predictive difference in the cohort of rib invasion. The results of the multivariable analysis revealed that the mortality with parietal pleura invasion plus tumor size ≤5cm were similar to patients with classification pT3 (P =0.761), and patients for parietal pleura invasion plus tumor size >5cm and pT4 had no stratified survival outcome (P =0.809). Patients identified as rib invasion had a poorer prognosis than patients for pT4 (P =0.037). CONCLUSIONS: Rib invasion has a poorer prognosis than pT4. Patients with parietal pleura invasion and tumor size with 5.1-7.0cm could be appropriately up-classified from pT3 to pT4. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9096107/ /pubmed/35574398 http://dx.doi.org/10.3389/fonc.2022.878482 Text en Copyright © 2022 Wu, Li, Li, Qiu, Xu, Lin, Ma, Li and Xie https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wu, Lei-Lei
Li, Chong-Wu
Li, Kun
Qiu, Li-Hong
Xu, Shu-Quan
Lin, Wei-Kang
Ma, Guo-Wei
Li, Zhi-Xin
Xie, Dong
The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title_full The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title_fullStr The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title_full_unstemmed The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title_short The Difference and Significance of Parietal Pleura Invasion and Rib Invasion in Pathological T Classification With Non-Small Cell Lung Cancer
title_sort difference and significance of parietal pleura invasion and rib invasion in pathological t classification with non-small cell lung cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096107/
https://www.ncbi.nlm.nih.gov/pubmed/35574398
http://dx.doi.org/10.3389/fonc.2022.878482
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