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Long-term health outcomes in young adults after Kawasaki disease
BACKGROUND: We compared the long-term health of adults with prior Kawasaki disease (KD) to controls and determined whether outcomes varied by coronary artery (CA) status. METHODS: We conducted a prospective cohort study of 258 KD subjects (mean 19 ± 9 years since KD) and 148 age-similar controls who...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096130/ https://www.ncbi.nlm.nih.gov/pubmed/35573651 http://dx.doi.org/10.1016/j.ijcha.2022.101039 |
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author | Daniels, Lori B. Roberts, Samantha Moreno, Elizabeth Tremoulet, Adriana H. Gordon, John B. Burns, Jane C. |
author_facet | Daniels, Lori B. Roberts, Samantha Moreno, Elizabeth Tremoulet, Adriana H. Gordon, John B. Burns, Jane C. |
author_sort | Daniels, Lori B. |
collection | PubMed |
description | BACKGROUND: We compared the long-term health of adults with prior Kawasaki disease (KD) to controls and determined whether outcomes varied by coronary artery (CA) status. METHODS: We conducted a prospective cohort study of 258 KD subjects (mean 19 ± 9 years since KD) and 148 age-similar controls who completed extensive health questionnaires. KD subjects were divided into 2 groups, Cohort 1: 109 subjects followed since KD diagnosis at our institution; Cohort 2: 149 KD subjects diagnosed elsewhere. RESULTS: KD subjects and controls were of similar age at the time of questionnaire completion (p = 0.50). Overall, 128 subjects (including 60 in Cohort 1) reported normal CAs during and after KD. Compared to controls, KD subjects with normal CAs reported several medical conditions with increased prevalence including migraine headaches, shortness of breath, and leg pain with walking, among others. When limited to Cohort 1, KD subjects were significantly more likely to report chest pain (47% vs 16%, p < 0.001) or palpitations (23% vs 10%, p = 0.01) compared to controls. Prevalence of depression was similar (7% vs 5%, p = 0.73). CONCLUSIONS: Despite always having normal CAs in the acute and subacute phases of KD, young adults with a history of KD with normal coronaries were more likely than controls to experience cardiovascular symptoms. These differences could be influenced by anxiety or depression, but report of depression was similar between groups. Whether these health differences reflect a heightened awareness of symptoms among KD subjects, or underlying vascular pathology (i.e. vasospasm, microvascular dysfunction, other) merits further study. |
format | Online Article Text |
id | pubmed-9096130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-90961302022-05-13 Long-term health outcomes in young adults after Kawasaki disease Daniels, Lori B. Roberts, Samantha Moreno, Elizabeth Tremoulet, Adriana H. Gordon, John B. Burns, Jane C. Int J Cardiol Heart Vasc Original Paper BACKGROUND: We compared the long-term health of adults with prior Kawasaki disease (KD) to controls and determined whether outcomes varied by coronary artery (CA) status. METHODS: We conducted a prospective cohort study of 258 KD subjects (mean 19 ± 9 years since KD) and 148 age-similar controls who completed extensive health questionnaires. KD subjects were divided into 2 groups, Cohort 1: 109 subjects followed since KD diagnosis at our institution; Cohort 2: 149 KD subjects diagnosed elsewhere. RESULTS: KD subjects and controls were of similar age at the time of questionnaire completion (p = 0.50). Overall, 128 subjects (including 60 in Cohort 1) reported normal CAs during and after KD. Compared to controls, KD subjects with normal CAs reported several medical conditions with increased prevalence including migraine headaches, shortness of breath, and leg pain with walking, among others. When limited to Cohort 1, KD subjects were significantly more likely to report chest pain (47% vs 16%, p < 0.001) or palpitations (23% vs 10%, p = 0.01) compared to controls. Prevalence of depression was similar (7% vs 5%, p = 0.73). CONCLUSIONS: Despite always having normal CAs in the acute and subacute phases of KD, young adults with a history of KD with normal coronaries were more likely than controls to experience cardiovascular symptoms. These differences could be influenced by anxiety or depression, but report of depression was similar between groups. Whether these health differences reflect a heightened awareness of symptoms among KD subjects, or underlying vascular pathology (i.e. vasospasm, microvascular dysfunction, other) merits further study. Elsevier 2022-05-04 /pmc/articles/PMC9096130/ /pubmed/35573651 http://dx.doi.org/10.1016/j.ijcha.2022.101039 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Paper Daniels, Lori B. Roberts, Samantha Moreno, Elizabeth Tremoulet, Adriana H. Gordon, John B. Burns, Jane C. Long-term health outcomes in young adults after Kawasaki disease |
title | Long-term health outcomes in young adults after Kawasaki disease |
title_full | Long-term health outcomes in young adults after Kawasaki disease |
title_fullStr | Long-term health outcomes in young adults after Kawasaki disease |
title_full_unstemmed | Long-term health outcomes in young adults after Kawasaki disease |
title_short | Long-term health outcomes in young adults after Kawasaki disease |
title_sort | long-term health outcomes in young adults after kawasaki disease |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096130/ https://www.ncbi.nlm.nih.gov/pubmed/35573651 http://dx.doi.org/10.1016/j.ijcha.2022.101039 |
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