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Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions
BACKGROUND: The effects of ostial coronary lesion (OCL) treatment with a drug-coated balloon (DCB) alone remain controversial. This retrospective study assessed the effectiveness and safety with DCB only strategy for OCL and the factors associated with target lesion revascularization (TLR) in these...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096279/ https://www.ncbi.nlm.nih.gov/pubmed/35572873 http://dx.doi.org/10.21037/jtd-22-270 |
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author | Zhang, Wenduo Ji, Fusui Yu, Xue Yang, Chenguang Wang, Xinyue |
author_facet | Zhang, Wenduo Ji, Fusui Yu, Xue Yang, Chenguang Wang, Xinyue |
author_sort | Zhang, Wenduo |
collection | PubMed |
description | BACKGROUND: The effects of ostial coronary lesion (OCL) treatment with a drug-coated balloon (DCB) alone remain controversial. This retrospective study assessed the effectiveness and safety with DCB only strategy for OCL and the factors associated with target lesion revascularization (TLR) in these patients. METHODS: The study retrospectively included patients whom had OCLs treated with a paclitaxel-eluting DCB only strategy from 1 May 2014 to 1 May 2017. Patients were divided into in-stent restenosis (ISR) and de novo (primary) groups. And all patients came back to hospital, and underwent clinical and also angiographic follow-up. RESULTS: Among the 44 patients with 55 OCLs, 12 (27.3%) were assigned to the ISR group and 32 (72.7%) to the de novo group. The outcomes included TLR, post-interventional lumen gain, and late lumen loss (LLL). Only 8 TLRs (7 ISR and 1 de novo) were observed after a mean follow-up of 16 months. The TLR rate in the de novo group was significantly lower than the ISR group (2.4% vs. 50%, P<0.001). The LLL was 0.07±0.63 mm. Logistic regression analysis showed that the TLR incidence was independently associated with the type of stenosis (ISR vs. de novo) after adjusting for sex [odds ratio (OR), 58.72; 95% confidence interval (CI): 4.42–779.94, P=0.002]. CONCLUSIONS: Treatment with DCB alone was beneficial to patients with OCLs, particularly those with de novo lesions. |
format | Online Article Text |
id | pubmed-9096279 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-90962792022-05-13 Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions Zhang, Wenduo Ji, Fusui Yu, Xue Yang, Chenguang Wang, Xinyue J Thorac Dis Original Article BACKGROUND: The effects of ostial coronary lesion (OCL) treatment with a drug-coated balloon (DCB) alone remain controversial. This retrospective study assessed the effectiveness and safety with DCB only strategy for OCL and the factors associated with target lesion revascularization (TLR) in these patients. METHODS: The study retrospectively included patients whom had OCLs treated with a paclitaxel-eluting DCB only strategy from 1 May 2014 to 1 May 2017. Patients were divided into in-stent restenosis (ISR) and de novo (primary) groups. And all patients came back to hospital, and underwent clinical and also angiographic follow-up. RESULTS: Among the 44 patients with 55 OCLs, 12 (27.3%) were assigned to the ISR group and 32 (72.7%) to the de novo group. The outcomes included TLR, post-interventional lumen gain, and late lumen loss (LLL). Only 8 TLRs (7 ISR and 1 de novo) were observed after a mean follow-up of 16 months. The TLR rate in the de novo group was significantly lower than the ISR group (2.4% vs. 50%, P<0.001). The LLL was 0.07±0.63 mm. Logistic regression analysis showed that the TLR incidence was independently associated with the type of stenosis (ISR vs. de novo) after adjusting for sex [odds ratio (OR), 58.72; 95% confidence interval (CI): 4.42–779.94, P=0.002]. CONCLUSIONS: Treatment with DCB alone was beneficial to patients with OCLs, particularly those with de novo lesions. AME Publishing Company 2022-04 /pmc/articles/PMC9096279/ /pubmed/35572873 http://dx.doi.org/10.21037/jtd-22-270 Text en 2022 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) . |
spellingShingle | Original Article Zhang, Wenduo Ji, Fusui Yu, Xue Yang, Chenguang Wang, Xinyue Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title | Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title_full | Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title_fullStr | Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title_full_unstemmed | Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title_short | Retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
title_sort | retrospective study of treatment with a drug-coated balloon alone is beneficial for ostial coronary lesions |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096279/ https://www.ncbi.nlm.nih.gov/pubmed/35572873 http://dx.doi.org/10.21037/jtd-22-270 |
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