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Interstitial lung disease and wedge resection are poor prognostic factors for non-small cell lung cancer

BACKGROUND: Although several prognostic factors in patients undergoing pulmonary resection with early-stage non-small cell lung cancer (NSCLC) have been reported, the risk factors are varied and have not been consistent among reports. METHODS: Clinical data of 540 patients with pathological stage IA...

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Detalles Bibliográficos
Autores principales: Motono, Nozomu, Ishikawa, Masahito, Iwai, Shun, Iijima, Yoshihito, Uramoto, Hidetaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096310/
https://www.ncbi.nlm.nih.gov/pubmed/35572877
http://dx.doi.org/10.21037/jtd-21-1757
Descripción
Sumario:BACKGROUND: Although several prognostic factors in patients undergoing pulmonary resection with early-stage non-small cell lung cancer (NSCLC) have been reported, the risk factors are varied and have not been consistent among reports. METHODS: Clinical data of 540 patients with pathological stage IA NSCLC were analyzed. Patient factors, such as the sex, age, comorbidities, carcinoembryonic antigen (CEA) level, and smoking history, and surgical factors, such as the operative approach and procedure, were collected and analyzed. RESULTS: There were significant prognostic differences in the relapse-free survival (RFS) depending on the presence of interstitial lung disease (P<0.0001), CEA level (P=0.007), and wedge resection (P=0.002). There were significant prognostic differences in the overall survival (OS) depending on the presence of interstitial lung disease (P=0.0015), CEA level (P<0.0001), and smoking history (P=0.0003). Interstitial lung disease [hazard ratio (HR): 7.725, P=0.003], the CEA level (HR: 1.923, P=0.045), and operative procedure (HR: 2.086, P=0.025) were risk factors for the RFS in a multivariate analysis. The smoking history (HR: 2.539, P=0.002) and CEA level (HR: 2.464, P=0.002) were risk factors for the OS in a multivariate analysis. CONCLUSIONS: Interstitial lung disease, the CEA level, and operative procedure were risk factors for the RFS, while the smoking history and CEA level were risk factors for the OS.