Cargando…

Association of marital status with cardiovascular outcome in patients with breast cancer

BACKGROUND: The influences of marital status on cardiovascular death risk in patients with breast cancer remained unclear. This study aimed to evaluate the associations of different marital status with cardiovascular death risk in patients with breast cancer. METHODS: A total of 182,666 female breas...

Descripción completa

Detalles Bibliográficos
Autores principales: Guan, Tianwang, Wang, Yuyan, Li, Feng, Chen, Dongting, Wei, Qingqian, Wang, Kenie, Zhang, Hanbin, Yang, Jinming, Zeng, Jin, Lai, Yanxian, Yang, Zhengxia, Liu, Cheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096314/
https://www.ncbi.nlm.nih.gov/pubmed/35572869
http://dx.doi.org/10.21037/jtd-21-1261
_version_ 1784705948774825984
author Guan, Tianwang
Wang, Yuyan
Li, Feng
Chen, Dongting
Wei, Qingqian
Wang, Kenie
Zhang, Hanbin
Yang, Jinming
Zeng, Jin
Lai, Yanxian
Yang, Zhengxia
Liu, Cheng
author_facet Guan, Tianwang
Wang, Yuyan
Li, Feng
Chen, Dongting
Wei, Qingqian
Wang, Kenie
Zhang, Hanbin
Yang, Jinming
Zeng, Jin
Lai, Yanxian
Yang, Zhengxia
Liu, Cheng
author_sort Guan, Tianwang
collection PubMed
description BACKGROUND: The influences of marital status on cardiovascular death risk in patients with breast cancer remained unclear. This study aimed to evaluate the associations of different marital status with cardiovascular death risk in patients with breast cancer. METHODS: A total of 182,666 female breast cancer patients were enrolled in this study from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2014, and was divided into two groups: married (N=107,043) and unmarried (N=75,623). A 1:1 propensity score matching (PSM) was applied to reduce inter-group bias between the two groups. Competing-risks model was used to assess the associations between different marital status and cardiovascular death risk in patients with breast cancer. RESULTS: After PSM, marital status was an independent predictor for cardiovascular death in patients with breast cancer. Unmarried condition was associated with increased cardiovascular death risk than married condition among breast cancer patients [unadjusted model: hazard ratio (HR) =2.012, 95% confidence interval (CI): 1.835–2.208, P<0.001; Model 1: HR =1.958, 95% CI: 1.785–2.148, P<0.001; Model 2: HR =1.954, 95% CI: 1.781–2.144, P<0.001; Model 3: HR =1.920, 95% CI: 1.748–2.107, P<0.001]. With the exception of separated condition (adjusted HR =0.886, 95% CI: 0.474–1.658, P=0.705), further unmarried subgroups analysis showed that the other three unmarried status were associated with increased cardiovascular death risk as follows: single (adjusted HR =1.623, 95% CI: 1.421–1.853, P<0.001), divorced (adjusted HR =1.394, 95% CI: 1.209–1.608, P<0.001), and widowed (adjusted HR =2.460, 95% CI: 2.227–2.717, P<0.001). In particularly, widowed condition showed the highest cardiovascular death risk in all 4 unmarried subgroups. CONCLUSIONS: Unmarried condition (e.g., single, divorced and widowed) was associated with elevated cardiovascular death risk compared with their married counterparts in patients with breast cancer, suggesting that more attention and humanistic care should be paid to unmarried breast cancer patients (especially the widowed patients) in the management of female breast cancer patients.
format Online
Article
Text
id pubmed-9096314
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-90963142022-05-13 Association of marital status with cardiovascular outcome in patients with breast cancer Guan, Tianwang Wang, Yuyan Li, Feng Chen, Dongting Wei, Qingqian Wang, Kenie Zhang, Hanbin Yang, Jinming Zeng, Jin Lai, Yanxian Yang, Zhengxia Liu, Cheng J Thorac Dis Original Article BACKGROUND: The influences of marital status on cardiovascular death risk in patients with breast cancer remained unclear. This study aimed to evaluate the associations of different marital status with cardiovascular death risk in patients with breast cancer. METHODS: A total of 182,666 female breast cancer patients were enrolled in this study from the Surveillance, Epidemiology, and End Results (SEER) database from 2010 to 2014, and was divided into two groups: married (N=107,043) and unmarried (N=75,623). A 1:1 propensity score matching (PSM) was applied to reduce inter-group bias between the two groups. Competing-risks model was used to assess the associations between different marital status and cardiovascular death risk in patients with breast cancer. RESULTS: After PSM, marital status was an independent predictor for cardiovascular death in patients with breast cancer. Unmarried condition was associated with increased cardiovascular death risk than married condition among breast cancer patients [unadjusted model: hazard ratio (HR) =2.012, 95% confidence interval (CI): 1.835–2.208, P<0.001; Model 1: HR =1.958, 95% CI: 1.785–2.148, P<0.001; Model 2: HR =1.954, 95% CI: 1.781–2.144, P<0.001; Model 3: HR =1.920, 95% CI: 1.748–2.107, P<0.001]. With the exception of separated condition (adjusted HR =0.886, 95% CI: 0.474–1.658, P=0.705), further unmarried subgroups analysis showed that the other three unmarried status were associated with increased cardiovascular death risk as follows: single (adjusted HR =1.623, 95% CI: 1.421–1.853, P<0.001), divorced (adjusted HR =1.394, 95% CI: 1.209–1.608, P<0.001), and widowed (adjusted HR =2.460, 95% CI: 2.227–2.717, P<0.001). In particularly, widowed condition showed the highest cardiovascular death risk in all 4 unmarried subgroups. CONCLUSIONS: Unmarried condition (e.g., single, divorced and widowed) was associated with elevated cardiovascular death risk compared with their married counterparts in patients with breast cancer, suggesting that more attention and humanistic care should be paid to unmarried breast cancer patients (especially the widowed patients) in the management of female breast cancer patients. AME Publishing Company 2022-04 /pmc/articles/PMC9096314/ /pubmed/35572869 http://dx.doi.org/10.21037/jtd-21-1261 Text en 2022 Journal of Thoracic Disease. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Guan, Tianwang
Wang, Yuyan
Li, Feng
Chen, Dongting
Wei, Qingqian
Wang, Kenie
Zhang, Hanbin
Yang, Jinming
Zeng, Jin
Lai, Yanxian
Yang, Zhengxia
Liu, Cheng
Association of marital status with cardiovascular outcome in patients with breast cancer
title Association of marital status with cardiovascular outcome in patients with breast cancer
title_full Association of marital status with cardiovascular outcome in patients with breast cancer
title_fullStr Association of marital status with cardiovascular outcome in patients with breast cancer
title_full_unstemmed Association of marital status with cardiovascular outcome in patients with breast cancer
title_short Association of marital status with cardiovascular outcome in patients with breast cancer
title_sort association of marital status with cardiovascular outcome in patients with breast cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096314/
https://www.ncbi.nlm.nih.gov/pubmed/35572869
http://dx.doi.org/10.21037/jtd-21-1261
work_keys_str_mv AT guantianwang associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT wangyuyan associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT lifeng associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT chendongting associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT weiqingqian associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT wangkenie associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT zhanghanbin associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT yangjinming associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT zengjin associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT laiyanxian associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT yangzhengxia associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer
AT liucheng associationofmaritalstatuswithcardiovascularoutcomeinpatientswithbreastcancer