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Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review

Spread of a novel coronavirus infection in 2019 caused by SARS-CoV-2 virus has become a real threat to public health all around the world. The new pandemic required the mobilization of all resources for effective treatment of COVID-19 patients. Extracorporeal apheresis methods were suggested as an a...

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Detalles Bibliográficos
Autores principales: Lezhnina, Arina, Lem, Violetta, Blatt, Nataliya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096332/
https://www.ncbi.nlm.nih.gov/pubmed/35578681
http://dx.doi.org/10.1007/s12668-022-00987-x
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author Lezhnina, Arina
Lem, Violetta
Blatt, Nataliya
author_facet Lezhnina, Arina
Lem, Violetta
Blatt, Nataliya
author_sort Lezhnina, Arina
collection PubMed
description Spread of a novel coronavirus infection in 2019 caused by SARS-CoV-2 virus has become a real threat to public health all around the world. The new pandemic required the mobilization of all resources for effective treatment of COVID-19 patients. Extracorporeal apheresis methods were suggested as an addition to the therapy of severe COVID-19 patients, especially when there is a threat of cytokine storm. Cytokine storm has a complex and not fully understood mechanism, and it can result in the multiple organ failure syndrome, associated with high mortality. The main cytokines that play the key role in the cytokine storm are IL-6, IL-10, and TNF-alpha. Removal of the target pro-inflammatory cytokines from the bloodstream can be beneficial in reducing the risk of complications as well as the mortality rate. We describe and compare different methods of extracorporeal apheresis: hemoadsorption, selective plasma filtration, and plasma exchange therapy in the context of their potential use in COVID-19 treatment.
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spelling pubmed-90963322022-05-12 Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review Lezhnina, Arina Lem, Violetta Blatt, Nataliya Bionanoscience Article Spread of a novel coronavirus infection in 2019 caused by SARS-CoV-2 virus has become a real threat to public health all around the world. The new pandemic required the mobilization of all resources for effective treatment of COVID-19 patients. Extracorporeal apheresis methods were suggested as an addition to the therapy of severe COVID-19 patients, especially when there is a threat of cytokine storm. Cytokine storm has a complex and not fully understood mechanism, and it can result in the multiple organ failure syndrome, associated with high mortality. The main cytokines that play the key role in the cytokine storm are IL-6, IL-10, and TNF-alpha. Removal of the target pro-inflammatory cytokines from the bloodstream can be beneficial in reducing the risk of complications as well as the mortality rate. We describe and compare different methods of extracorporeal apheresis: hemoadsorption, selective plasma filtration, and plasma exchange therapy in the context of their potential use in COVID-19 treatment. Springer US 2022-05-12 2022 /pmc/articles/PMC9096332/ /pubmed/35578681 http://dx.doi.org/10.1007/s12668-022-00987-x Text en © The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Lezhnina, Arina
Lem, Violetta
Blatt, Nataliya
Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title_full Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title_fullStr Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title_full_unstemmed Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title_short Application of Extracorporeal Apheresis in Treatment of COVID-19: a Rapid Review
title_sort application of extracorporeal apheresis in treatment of covid-19: a rapid review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096332/
https://www.ncbi.nlm.nih.gov/pubmed/35578681
http://dx.doi.org/10.1007/s12668-022-00987-x
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