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The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study

BACKGROUND: The association between occurrence of thyroid nodules (TNs) and trace elements detectable in blood are still inconclusive. The present study sought to determine the relationship between selected trace elements and TNs in the iodine-adequate area of Guangdong, China. METHODS: A total of 1...

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Autores principales: Zeng, Huixian, Hu, Yuanyuan, Luo, Yaosheng, Ye, Yanshi, Song, Cheng, Yu, Genfeng, Chen, Zhi, Liu, Siyang, Liang, Yongqian, Liu, Lingling, Wan, Heng, Shen, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096353/
https://www.ncbi.nlm.nih.gov/pubmed/35571937
http://dx.doi.org/10.3389/fnut.2022.870873
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author Zeng, Huixian
Hu, Yuanyuan
Luo, Yaosheng
Ye, Yanshi
Song, Cheng
Yu, Genfeng
Chen, Zhi
Liu, Siyang
Liang, Yongqian
Liu, Lingling
Wan, Heng
Shen, Jie
author_facet Zeng, Huixian
Hu, Yuanyuan
Luo, Yaosheng
Ye, Yanshi
Song, Cheng
Yu, Genfeng
Chen, Zhi
Liu, Siyang
Liang, Yongqian
Liu, Lingling
Wan, Heng
Shen, Jie
author_sort Zeng, Huixian
collection PubMed
description BACKGROUND: The association between occurrence of thyroid nodules (TNs) and trace elements detectable in blood are still inconclusive. The present study sought to determine the relationship between selected trace elements and TNs in the iodine-adequate area of Guangdong, China. METHODS: A total of 1,048 participants from four communities were enrolled. A number of medical checkups were conducted to collect relevant data on anthropometric parameters, blood pressure, glucose blood levels and lipid profiles, as well as data on thyroid function, presence of thyroid autoantibodies, and trace elements. Presence of TN was diagnosed by ultrasonography. RESULTS: Of the 1048 participants (49.5 ± 14.4 years old), 543 participants (51.8%) had TNs. Serum copper, magnesium and zinc levels are associated with the presence of TNs among healthy subjects. Subjects with higher levels of zinc, magnesium and copper had 1.23-fold, 1.04-fold, and 1.007-fold increased risks of the prevalence of TNs (P = 0.013, 0.017, and < 0.001, resp). Compared with the first quartile of copper content in serum, participants in the fourth quartile had the highest prevalence of TNs with an odds ratio of 8.90 (95% confidence interval (CI) 5.41, 14.94) among all participants. Women in the third quartile of magnesium level had a 1.86-fold (95%CI 1.05, 3.31) risk of the prevalence of TNs. Subjects in the highest quartile of zinc level had a 1.82-fold (95%CI 1.06, 3.16) risk of the prevalence of TNs in females. CONCLUSION: TNs were found highly prevalent in females in the investigated population from an iodine-adequate area of Guangdong, China. The imbalance of selected trace elements (copper, magnesium and zinc) in the body is related to the presence of TNs among healthy subjects. The observed correlation of copper on TNs warrants further studies.
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spelling pubmed-90963532022-05-13 The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study Zeng, Huixian Hu, Yuanyuan Luo, Yaosheng Ye, Yanshi Song, Cheng Yu, Genfeng Chen, Zhi Liu, Siyang Liang, Yongqian Liu, Lingling Wan, Heng Shen, Jie Front Nutr Nutrition BACKGROUND: The association between occurrence of thyroid nodules (TNs) and trace elements detectable in blood are still inconclusive. The present study sought to determine the relationship between selected trace elements and TNs in the iodine-adequate area of Guangdong, China. METHODS: A total of 1,048 participants from four communities were enrolled. A number of medical checkups were conducted to collect relevant data on anthropometric parameters, blood pressure, glucose blood levels and lipid profiles, as well as data on thyroid function, presence of thyroid autoantibodies, and trace elements. Presence of TN was diagnosed by ultrasonography. RESULTS: Of the 1048 participants (49.5 ± 14.4 years old), 543 participants (51.8%) had TNs. Serum copper, magnesium and zinc levels are associated with the presence of TNs among healthy subjects. Subjects with higher levels of zinc, magnesium and copper had 1.23-fold, 1.04-fold, and 1.007-fold increased risks of the prevalence of TNs (P = 0.013, 0.017, and < 0.001, resp). Compared with the first quartile of copper content in serum, participants in the fourth quartile had the highest prevalence of TNs with an odds ratio of 8.90 (95% confidence interval (CI) 5.41, 14.94) among all participants. Women in the third quartile of magnesium level had a 1.86-fold (95%CI 1.05, 3.31) risk of the prevalence of TNs. Subjects in the highest quartile of zinc level had a 1.82-fold (95%CI 1.06, 3.16) risk of the prevalence of TNs in females. CONCLUSION: TNs were found highly prevalent in females in the investigated population from an iodine-adequate area of Guangdong, China. The imbalance of selected trace elements (copper, magnesium and zinc) in the body is related to the presence of TNs among healthy subjects. The observed correlation of copper on TNs warrants further studies. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9096353/ /pubmed/35571937 http://dx.doi.org/10.3389/fnut.2022.870873 Text en Copyright © 2022 Zeng, Hu, Luo, Ye, Song, Yu, Chen, Liu, Liang, Liu, Wan and Shen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zeng, Huixian
Hu, Yuanyuan
Luo, Yaosheng
Ye, Yanshi
Song, Cheng
Yu, Genfeng
Chen, Zhi
Liu, Siyang
Liang, Yongqian
Liu, Lingling
Wan, Heng
Shen, Jie
The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title_full The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title_fullStr The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title_full_unstemmed The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title_short The Association of Thyroid Nodules With Blood Trace Elements Identified in a Cross-Section Study
title_sort association of thyroid nodules with blood trace elements identified in a cross-section study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096353/
https://www.ncbi.nlm.nih.gov/pubmed/35571937
http://dx.doi.org/10.3389/fnut.2022.870873
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