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Detection of Chimeric Cellular: HIV mRNAs Generated Through Aberrant Splicing in HIV-1 Latently Infected Resting CD4+ T Cells

Latent HIV-1 provirus in infected individuals on suppressive therapy does not always remain transcriptionally silent. Both HIV-1 LTR and human gene promoter derived transcriptional events can contribute HIV-1 sequences to the mRNA produced in the cell. In addition, chimeric cellular:HIV mRNA can ari...

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Detalles Bibliográficos
Autores principales:	Lee, Michelle Y-H, Khoury, Georges, Olshansky, Moshe, Sonza, Secondo, Carter, Glen P., McMahon, James, Stinear, Timothy P., Turner, Stephen J., Lewin, Sharon R., Purcell, Damian F. J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Cellular and Infection Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096486/ https://www.ncbi.nlm.nih.gov/pubmed/35573784 http://dx.doi.org/10.3389/fcimb.2022.855290

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