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Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096773/ https://www.ncbi.nlm.nih.gov/pubmed/35551643 http://dx.doi.org/10.1186/s13287-022-02876-2 |
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author | Zhou, Li Zhu, Huimin Bai, Xue Huang, Jiagui Chen, Yue Wen, Jun Li, Xuemei Wu, Bowen Tan, Yongjun Tian, Mingfen Ren, Jiangxia Li, Mengxia Yang, Qin |
author_facet | Zhou, Li Zhu, Huimin Bai, Xue Huang, Jiagui Chen, Yue Wen, Jun Li, Xuemei Wu, Bowen Tan, Yongjun Tian, Mingfen Ren, Jiangxia Li, Mengxia Yang, Qin |
author_sort | Zhou, Li |
collection | PubMed |
description | Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke. |
format | Online Article Text |
id | pubmed-9096773 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90967732022-05-12 Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke Zhou, Li Zhu, Huimin Bai, Xue Huang, Jiagui Chen, Yue Wen, Jun Li, Xuemei Wu, Bowen Tan, Yongjun Tian, Mingfen Ren, Jiangxia Li, Mengxia Yang, Qin Stem Cell Res Ther Review Ischemic stroke is one of the major causes of death and disability in the world. Currently, most patients cannot choose intravenous thrombolysis or intravascular mechanical thrombectomy because of narrow therapeutic windows and severe complications. Stem cell transplantation is an emerging treatment and has been studied in various central nervous system diseases. Animal and clinical studies showed that transplantation of mesenchymal stem cells (MSCs) could alleviate neurological deficits and bring hope for ischemic stroke treatment. This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke. BioMed Central 2022-05-12 /pmc/articles/PMC9096773/ /pubmed/35551643 http://dx.doi.org/10.1186/s13287-022-02876-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhou, Li Zhu, Huimin Bai, Xue Huang, Jiagui Chen, Yue Wen, Jun Li, Xuemei Wu, Bowen Tan, Yongjun Tian, Mingfen Ren, Jiangxia Li, Mengxia Yang, Qin Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title_full | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title_fullStr | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title_full_unstemmed | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title_short | Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
title_sort | potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9096773/ https://www.ncbi.nlm.nih.gov/pubmed/35551643 http://dx.doi.org/10.1186/s13287-022-02876-2 |
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