A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diabetic-like kidney organoids exhibited higher viral...

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Detalles Bibliográficos
Autores principales: Garreta, Elena, Prado, Patricia, Stanifer, Megan L., Monteil, Vanessa, Marco, Andrés, Ullate-Agote, Asier, Moya-Rull, Daniel, Vilas-Zornoza, Amaia, Tarantino, Carolina, Romero, Juan Pablo, Jonsson, Gustav, Oria, Roger, Leopoldi, Alexandra, Hagelkruys, Astrid, Gallo, Maria, González, Federico, Domingo-Pedrol, Pere, Gavaldà, Aleix, del Pozo, Carmen Hurtado, Hasan Ali, Omar, Ventura-Aguiar, Pedro, Campistol, Josep María, Prosper, Felipe, Mirazimi, Ali, Boulant, Steeve, Penninger, Josef M., Montserrat, Nuria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097013/
https://www.ncbi.nlm.nih.gov/pubmed/35561674
http://dx.doi.org/10.1016/j.cmet.2022.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097013/
https://www.ncbi.nlm.nih.gov/pubmed/35561674
http://dx.doi.org/10.1016/j.cmet.2022.04.009

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