Cargando…

A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells

It is not well understood why diabetic individuals are more prone to develop severe COVID-19. To this, we here established a human kidney organoid model promoting early hallmarks of diabetic kidney disease development. Upon SARS-CoV-2 infection, diabetic-like kidney organoids exhibited higher viral...

Descripción completa

Detalles Bibliográficos
Autores principales:	Garreta, Elena, Prado, Patricia, Stanifer, Megan L., Monteil, Vanessa, Marco, Andrés, Ullate-Agote, Asier, Moya-Rull, Daniel, Vilas-Zornoza, Amaia, Tarantino, Carolina, Romero, Juan Pablo, Jonsson, Gustav, Oria, Roger, Leopoldi, Alexandra, Hagelkruys, Astrid, Gallo, Maria, González, Federico, Domingo-Pedrol, Pere, Gavaldà, Aleix, del Pozo, Carmen Hurtado, Hasan Ali, Omar, Ventura-Aguiar, Pedro, Campistol, Josep María, Prosper, Felipe, Mirazimi, Ali, Boulant, Steeve, Penninger, Josef M., Montserrat, Nuria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097013/ https://www.ncbi.nlm.nih.gov/pubmed/35561674 http://dx.doi.org/10.1016/j.cmet.2022.04.009

Ejemplares similares

Protocol for SARS-CoV-2 infection of kidney organoids derived from human pluripotent stem cells
por: Garreta, Elena, et al.
Publicado: (2022)

Revealing cell populations catching the early stages of human embryo development in naive pluripotent stem cell cultures
por: Moya-Jódar, Marta, et al.
Publicado: (2022)

Reptilian Transcriptomes v2.0: An Extensive Resource for Sauropsida Genomics and Transcriptomics
por: Tzika, Athanasia C., et al.
Publicado: (2015)

Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
por: Monteil, Vanessa, et al.
Publicado: (2020)

Dynamics of Virus-Receptor Interactions in Virus Binding, Signaling, and Endocytosis
por: Boulant, Steeve, et al.
Publicado: (2015)

Differential Regulation of Type I and Type III Interferon Signaling
por: Stanifer, Megan L., et al.
Publicado: (2019)

Somitic positional information guides self-organized patterning of snake scales
por: Tzika, Athanasia C., et al.
Publicado: (2023)

Regionalization of the antiviral response in the gastrointestinal tract to provide spatially controlled host/pathogen interactions
por: Stanifer, Megan L., et al.
Publicado: (2023)

Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes
por: Rodríguez-Carballo, Eddie, et al.
Publicado: (2019)

Development of Feline Ileum- and Colon-Derived Organoids and Their Potential Use to Support Feline Coronavirus Infection
por: Tekes, Gergely, et al.
Publicado: (2020)

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
por: Stanifer, Megan L., et al.
Publicado: (2020)

Reovirus inhibits interferon production by sequestering IRF3 into viral factories
por: Stanifer, Megan L., et al.
Publicado: (2017)

One-Step In Vitro Generation of ETV2-Null Pig Embryos
por: Moya-Jódar, Marta, et al.
Publicado: (2022)

Gene therapy restores the transcriptional program of hematopoietic stem cells in Fanconi anemia
por: Lasaga, Miren, et al.
Publicado: (2023)

Low-density lipoprotein receptor–related protein 1 (LRP1) as an auxiliary host factor for RNA viruses
por: Devignot, Stephanie, et al.
Publicado: (2023)

TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
por: Koch, Jana, et al.
Publicado: (2021)

Increased Sensitivity of SARS-CoV-2 to Type III Interferon in Human Intestinal Epithelial Cells
por: Metz-Zumaran, Camila, et al.
Publicado: (2022)

Type III and Not Type I Interferons Efficiently Prevent the Spread of Rotavirus in Human Intestinal Epithelial Cells
por: Doldan, Patricio, et al.
Publicado: (2022)

Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections
por: Monteil, Vanessa, et al.
Publicado: (2023)

Similar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin–Darby canine kidney cells
por: Boulant, Steeve, et al.
Publicado: (2013)

Genome mapping of a LYST mutation in corn snakes indicates that vertebrate chromatophore vesicles are lysosome-related organelles
por: Ullate-Agote, Asier, et al.
Publicado: (2020)

Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
por: Batlle, Daniel, et al.
Publicado: (2022)

The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity
por: Ramirez Alvarez, Carlos, et al.
Publicado: (2021)

The link between menin and pleiotrophin in the tumor biology of pancreatic neuroendocrine neoplasms
por: He, Liping, et al.
Publicado: (2022)

Teratogenic Rubella Virus Alters the Endodermal Differentiation Capacity of Human Induced Pluripotent Stem Cells
por: Bilz, Nicole C., et al.
Publicado: (2019)

Barre & milieu
por: Padovan, Sylvia
Publicado: (1990)

Rubella Virus Strain-Associated Differences in the Induction of Oxidative Stress Are Independent of Their Interferon Activation
por: Zobel, Sarah, et al.
Publicado: (2018)

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
por: Stanifer, Megan L., et al.
Publicado: (2020)

Conserved Induction of Distinct Antiviral Signalling Kinetics by Primate Interferon Lambda 4 Proteins
por: Guo, Cuncai, et al.
Publicado: (2021)

Invasiveness of Escherichia coli Is Associated with an IncFII Plasmid
por: Krall, Lars Johannes, et al.
Publicado: (2021)

Cell, Organism and Milieu
Publicado: (1960)

Le milieu interstellaire
por: Lequeux, Jacques, et al.
Publicado: (2002)

Transforming the Milieu of Cancer
por: Alschuler, Lise, et al.
Publicado: (2012)

SARS-CoV-2 structure and replication characterized by in situ cryo-electron tomography
por: Klein, Steffen, et al.
Publicado: (2020)

Redirecting Imipramine against Bluetongue Virus Infection: Insights from a Genome-wide Haploid Screening Study
por: John, Lijo, et al.
Publicado: (2022)

Extended methods for spatial cell classification with DBSCAN-CellX
por: Küchenhoff, Leonie, et al.
Publicado: (2023)

Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells
por: Bobadilla Muñoz, Miriam, et al.
Publicado: (2023)

Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut
por: Pervolaraki, Kalliopi, et al.
Publicado: (2017)

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
por: Petitjean, Simon J. L., et al.
Publicado: (2022)

Author Correction: Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection
por: Petitjean, Simon J. L., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_96qfifkhuam0skgnh617u3f1bh