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Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents
Across biological scales, gene-regulatory networks employ autorepression (negative feedback) to maintain homeostasis and minimize failure from aberrant expression. Here, we present a proof of concept that disrupting transcriptional negative feedback dysregulates viral gene expression to therapeutica...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097017/ https://www.ncbi.nlm.nih.gov/pubmed/35561685 http://dx.doi.org/10.1016/j.cell.2022.04.022 |