Disrupting autorepression circuitry generates “open-loop lethality” to yield escape-resistant antiviral agents

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Across biological scales, gene-regulatory networks employ autorepression (negative feedback) to maintain homeostasis and minimize failure from aberrant expression. Here, we present a proof of concept that disrupting transcriptional negative feedback dysregulates viral gene expression to therapeutica...

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Detalles Bibliográficos
Autores principales: Chaturvedi, Sonali, Pablo, Michael, Wolf, Marie, Rosas-Rivera, Daniel, Calia, Giuliana, Kumar, Arjun J., Vardi, Noam, Du, Kelvin, Glazier, Joshua, Ke, Ruian, Chan, Matilda F., Perelson, Alan S., Weinberger, Leor S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2022
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097017/
https://www.ncbi.nlm.nih.gov/pubmed/35561685
http://dx.doi.org/10.1016/j.cell.2022.04.022
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