Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells

Atractylenolide-1 (AT-1), a natural active ingredient extracted from Atractylodes macrocephala, was reported to have good anti-fibrotic and anti-inflammatory effects. Osteogenic changes induced by the inflammation of valve interstitial cells (VICs) play a role in the development of calcified aortic...

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Detalles Bibliográficos
Autores principales: Wang, Jie, Zhang, Penghua, Zhang, Jing, Ma, Zhaohui, Tian, Xingqin, Liu, Yan, Lv, Guanghui, Qu, Linghang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097085/
https://www.ncbi.nlm.nih.gov/pubmed/35571096
http://dx.doi.org/10.3389/fphar.2022.899775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097085/
https://www.ncbi.nlm.nih.gov/pubmed/35571096
http://dx.doi.org/10.3389/fphar.2022.899775

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