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Preclinical validation and phase I trial of 4-hydroxysalicylanilide, targeting ribonucleotide reductase mediated dNTP synthesis in multiple myeloma
BACKGROUND: Aberrant DNA repair pathways contribute to malignant transformation or disease progression and the acquisition of drug resistance in multiple myeloma (MM); therefore, these pathways could be therapeutically exploited. Ribonucleotide reductase (RNR) is the rate-limiting enzyme for the bio...
Autores principales: | Xie, Yongsheng, Wang, Yingcong, Xu, Zhijian, Lu, Yumeng, Song, Dongliang, Gao, Lu, Yu, Dandan, Li, Bo, Chen, Gege, Zhang, Hui, Feng, Qilin, Zhang, Yong, Hu, Ke, Huang, Cheng, Peng, Yu, Wu, Xiaosong, Mao, Zhiyong, Shao, Jimin, Zhu, Weiliang, Shi, Jumei |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097096/ https://www.ncbi.nlm.nih.gov/pubmed/35546402 http://dx.doi.org/10.1186/s12929-022-00813-2 |
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