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Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study

BACKGROUND: Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain. METHODS: Data from the Atherosclerosis Risk in Communities (ARIC)...

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Autores principales: Zeng, Xiaoqi, Jiang, Shanshan, Ruan, Simin, Zhu, Lijun, Lian, Huining, Liu, Minfeng, Guo, Zhaoze, Guo, Jingyun, Ye, Changsheng, Cheng, Yunjiu, Dong, Jianyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097171/
https://www.ncbi.nlm.nih.gov/pubmed/35549892
http://dx.doi.org/10.1186/s12885-022-09604-2
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author Zeng, Xiaoqi
Jiang, Shanshan
Ruan, Simin
Zhu, Lijun
Lian, Huining
Liu, Minfeng
Guo, Zhaoze
Guo, Jingyun
Ye, Changsheng
Cheng, Yunjiu
Dong, Jianyu
author_facet Zeng, Xiaoqi
Jiang, Shanshan
Ruan, Simin
Zhu, Lijun
Lian, Huining
Liu, Minfeng
Guo, Zhaoze
Guo, Jingyun
Ye, Changsheng
Cheng, Yunjiu
Dong, Jianyu
author_sort Zeng, Xiaoqi
collection PubMed
description BACKGROUND: Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain. METHODS: Data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort of middle-aged women, were used to investigate the association of individual and combined cardiovascular risk factors with breast cancer. Cox proportional hazards models were applied to calculate the hazard ratio (HR) and 95% confidence intervals (CI). RESULTS: A total of 7501 women were included. During a mean follow-up of 19.7 years, 576 women were diagnosed with breast cancer. White women and premenopausal status were independently associated with increased risk of breast cancer. Of the individual cardiovascular risk factors, only obesity was independently associated with an increased risk of breast cancer (HR 1.29, 95% CI 1.04–1.61). Compared with women without cardiovascular risk factors, women having three or greater, but not those with fewer than three cardiovascular risk factors, had a significantly higher risk of developing breast cancer (HR 1.27, 95% CI 1.06–1.53). Subgroup analyses indicated that women with three or greater cardiovascular risk factors had higher risk of breast cancer among postmenopausal Black women, but not among premenopausal Black and White women. CONCLUSIONS: Combinations of cardiovascular risk factors are associated with increased risk of breast cancer in middle-aged women, especially in postmenopausal Black women. Joint interventions to modify cardiovascular risk factors could be used to prevent breast cancer in these higher-risk individuals.
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spelling pubmed-90971712022-05-13 Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study Zeng, Xiaoqi Jiang, Shanshan Ruan, Simin Zhu, Lijun Lian, Huining Liu, Minfeng Guo, Zhaoze Guo, Jingyun Ye, Changsheng Cheng, Yunjiu Dong, Jianyu BMC Cancer Research Article BACKGROUND: Several studies have demonstrated that cardiovascular risk factors play a role in the etiology of breast cancer. However, the combined effect of cardiovascular risk factors on the risk of breast cancer is still uncertain. METHODS: Data from the Atherosclerosis Risk in Communities (ARIC) study, a prospective cohort of middle-aged women, were used to investigate the association of individual and combined cardiovascular risk factors with breast cancer. Cox proportional hazards models were applied to calculate the hazard ratio (HR) and 95% confidence intervals (CI). RESULTS: A total of 7501 women were included. During a mean follow-up of 19.7 years, 576 women were diagnosed with breast cancer. White women and premenopausal status were independently associated with increased risk of breast cancer. Of the individual cardiovascular risk factors, only obesity was independently associated with an increased risk of breast cancer (HR 1.29, 95% CI 1.04–1.61). Compared with women without cardiovascular risk factors, women having three or greater, but not those with fewer than three cardiovascular risk factors, had a significantly higher risk of developing breast cancer (HR 1.27, 95% CI 1.06–1.53). Subgroup analyses indicated that women with three or greater cardiovascular risk factors had higher risk of breast cancer among postmenopausal Black women, but not among premenopausal Black and White women. CONCLUSIONS: Combinations of cardiovascular risk factors are associated with increased risk of breast cancer in middle-aged women, especially in postmenopausal Black women. Joint interventions to modify cardiovascular risk factors could be used to prevent breast cancer in these higher-risk individuals. BioMed Central 2022-05-12 /pmc/articles/PMC9097171/ /pubmed/35549892 http://dx.doi.org/10.1186/s12885-022-09604-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Zeng, Xiaoqi
Jiang, Shanshan
Ruan, Simin
Zhu, Lijun
Lian, Huining
Liu, Minfeng
Guo, Zhaoze
Guo, Jingyun
Ye, Changsheng
Cheng, Yunjiu
Dong, Jianyu
Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title_full Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title_fullStr Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title_full_unstemmed Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title_short Cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
title_sort cardiovascular risk factors and breast cancer incidence in a large middle-aged cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097171/
https://www.ncbi.nlm.nih.gov/pubmed/35549892
http://dx.doi.org/10.1186/s12885-022-09604-2
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