Cargando…

Design, Synthesis, and Molecular Modeling Studies of a Novel Benzimidazole as an Aromatase Inhibitor

[Image: see text] In this study, a series of novel 1,3,4-oxadiazole-benzimidazole derivatives were designed and synthesized. Their cytotoxic activities against five cancer cell lines, including A549, MCF-7, C6, HepG2, and HeLa, were evaluated by the MTT assay. The compounds 5b,c showed satisfactory...

Descripción completa

Detalles Bibliográficos
Autores principales:	Çevik, Ulviye Acar, Celik, Ismail, Mella, Jaime, Mellado, Marco, Özkay, Yusuf, Kaplancıklı, Zafer Asım
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097188/ https://www.ncbi.nlm.nih.gov/pubmed/35571854 http://dx.doi.org/10.1021/acsomega.2c01497

Ejemplares similares

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Synthesis and Molecular Docking of New N-Acyl Hydrazones-Benzimidazole as hCA I and II Inhibitors
por: Küçükoğlu, Kaan, et al.
Publicado: (2023)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
por: Acar Cevik, Ulviye, et al.
Publicado: (2019)

Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
por: Kaplancıklı, Zafer Asım, et al.
Publicado: (2017)

Synthesis, Molecular Docking, Dynamics, Quantum-Chemical Computation, and Antimicrobial Activity Studies of Some New Benzimidazole–Thiadiazole Hybrids
por: Celik, Ismail, et al.
Publicado: (2022)

Synthesis of Benzimidazole-1,2,4-triazole Derivatives as Potential Antifungal Agents Targeting 14α-Demethylase
por: Güzel, Emir, et al.
Publicado: (2023)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Design, Synthesis, and Structure–Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer’s Disease
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and Anticandidal Activity of New Imidazole-Chalcones
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
por: Levent, Serkan, et al.
Publicado: (2017)

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
por: Osmaniye, Derya, et al.
Publicado: (2019)

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
por: Çavuşoğlu, Betül Kaya, et al.
Publicado: (2017)

Pharmacological and Toxicological Screening of Novel Benzimidazole-Morpholine Derivatives as Dual-Acting Inhibitors
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Synthesis of New Fluoro-Benzimidazole Derivatives as an Approach towards the Discovery of Novel Intestinal Antiseptic Drug Candidates
por: Çevik, Ulviye Acar, et al.
Publicado: (2017)

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2018)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors
por: Haji Ali, Sazan, et al.
Publicado: (2022)

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease
por: Hussein, Weiam, et al.
Publicado: (2018)

Design, Synthesis, and Biological Evaluation Studies of Novel Naphthalene-Chalcone Hybrids As Antimicrobial, Anticandidal, Anticancer, and VEGFR-2 Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis and Antidepressant Activity Profile of Some Novel Benzothiazole Derivatives
por: Demir Özkay, Ümide, et al.
Publicado: (2017)

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2022)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2021)

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors
por: Kaya, Betül, et al.
Publicado: (2017)

Synthesis, Antifungal Activities, Molecular Docking and Molecular Dynamic Studies of Novel Quinoxaline-Triazole Compounds
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Antinociceptive Agents
por: Altıntop, Mehlika Dilek, et al.
Publicado: (2016)

The 4-(dimethylaminoalkyl)piperazine inhibitors of α-glucosidase: allosteric enzyme inhibition and identification of interacting chemical groups
por: GHANI, Usman, et al.
Publicado: (2022)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents
por: Kaplancikli, Zafer Asim
Publicado: (2011)

Synthesis of Novel Benzazole Derivatives and Evaluation of Their Antidepressant-Like Activities with Possible Underlying Mechanisms
por: Tokgöz, Gamze, et al.
Publicado: (2018)

Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
por: Karaca, Şevval, et al.
Publicado: (2022)

Synthesis and Evaluation of New 1,5-Diaryl-3-[4-(methyl-sulfonyl)phenyl]-4,5-dihydro-1H-pyrazole Derivatives as Potential Antidepressant Agents
por: Özdemir, Ahmet, et al.
Publicado: (2015)

Design and Synthesis of New Benzimidazole and Pyrimidine Derivatives as α-glucosidase Inhibitor
por: Mobinikhaledi, Akbar, et al.
Publicado: (2015)

Design, Synthesis and Biological Evaluation of Aromatase Inhibitors Based on Sulfonates and Sulfonamides of Resveratrol
por: Fantacuzzi, Marialuigia, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_qtahgcvbr19o7rvirhcpi91ms4