Production of Triple-Gene (GGTA1, B2M and CIITA)-Modified Donor Pigs for Xenotransplantation

Activation of human immune T-cells by swine leukocyte antigens class I (SLA-I) and class II (SLA-II) leads to xenograft destruction. Here, we generated the GGTA1, B2M, and CIITA (GBC) triple-gene-modified Diannan miniature pigs, analyzed the transcriptome of GBC-modified peripheral blood mononuclear...

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Detalles Bibliográficos
Autores principales: Xu, Kaixiang, Yu, Honghao, Chen, Shuhan, Zhang, Yaxuan, Guo, Jianxiong, Yang, Chang, Jiao, Deling, Nguyen, Tien Dat, Zhao, Heng, Wang, Jiaoxiang, Wei, Taiyun, Li, Honghui, Jia, Baoyu, Jamal, Muhammad Ameen, Zhao, Hong-Ye, Huang, Xingxu, Wei, Hong-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Veterinary Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097228/
https://www.ncbi.nlm.nih.gov/pubmed/35573408
http://dx.doi.org/10.3389/fvets.2022.848833

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