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Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women
BACKGROUND: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food suppleme...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097231/ https://www.ncbi.nlm.nih.gov/pubmed/35545756 http://dx.doi.org/10.1186/s12884-022-04725-9 |
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author | Luo, Caihong Li, Zhiju Lu, Yunya Wei, Fang Suo, Dongmei Lan, Shiyan Ren, Zhengyuan Jiang, Runchang Huang, Fang Chen, Aiyue Jiang, Liejun Huang, Huayi Guo, Xiaoling |
author_facet | Luo, Caihong Li, Zhiju Lu, Yunya Wei, Fang Suo, Dongmei Lan, Shiyan Ren, Zhengyuan Jiang, Runchang Huang, Fang Chen, Aiyue Jiang, Liejun Huang, Huayi Guo, Xiaoling |
author_sort | Luo, Caihong |
collection | PubMed |
description | BACKGROUND: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women. METHODS: A total of 1516 pregnant women whose blood glucose were normal before pregnancy in the city of Foshan in Guangdong, China were enrolled in this study. GDM was diagnosed between 24 to 28 weeks of pregnancy following the guidelines from the American Diabetes Association. Maternal serum 25(OH)D and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. RESULTS: The average 25(OH)D concentration was 59.1 ± 12.6 nmol/L. None of the study subjects had 25(OH)D < 25 nmol/L; 434 (28.6%) women had 25(OH)D deficiency (< 50 nmol/L), 882 women (58.2%) had 25(OH)D insufficiency (50–74 mmol/L) and 200 women (13.2%) had 25(OH)D sufficiency (≥ 75 nmol/L). There were 264 (17.4%) women diagnosed with GDM. There was not, however, an association between serum 25(OH)D in early pregnancy and GDM. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum 25(OH)D levels. There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. This study did not find an association between serum 25(OH)D and bone density. CONCLUSIONS: There were no associations between maternal serum 25(OH)D concentration in early pregnancy and the risk of GDM or bone density. There were, however, correlations between serum 25(OH)D and parity, seasoning at sampling, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factor thrombin time, which need further study to explain their pathophysiology and clinical significance. |
format | Online Article Text |
id | pubmed-9097231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90972312022-05-13 Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women Luo, Caihong Li, Zhiju Lu, Yunya Wei, Fang Suo, Dongmei Lan, Shiyan Ren, Zhengyuan Jiang, Runchang Huang, Fang Chen, Aiyue Jiang, Liejun Huang, Huayi Guo, Xiaoling BMC Pregnancy Childbirth Research BACKGROUND: The association between serum 25-hydroxy vitamin D (25(OH)D) status and gestational diabetes mellitus (GDM) gained attention in recent years, however the conclusion is still controversial due to many interfering factors, such as region of living, environment, lifestyle, and food supplements. Other metabolites (laboratory parameters) are also important in reflecting gestational states. This study aimed to investigate the association of serum 25(OH)D status in early pregnancy with GDM and other laboratory parameters in pregnant women. METHODS: A total of 1516 pregnant women whose blood glucose were normal before pregnancy in the city of Foshan in Guangdong, China were enrolled in this study. GDM was diagnosed between 24 to 28 weeks of pregnancy following the guidelines from the American Diabetes Association. Maternal serum 25(OH)D and other laboratory parameters—including hematology, coagulation, chemistry, and bone density—were measured utilizing various analytical methods in clinical laboratory at gestational weeks 11 to 14. RESULTS: The average 25(OH)D concentration was 59.1 ± 12.6 nmol/L. None of the study subjects had 25(OH)D < 25 nmol/L; 434 (28.6%) women had 25(OH)D deficiency (< 50 nmol/L), 882 women (58.2%) had 25(OH)D insufficiency (50–74 mmol/L) and 200 women (13.2%) had 25(OH)D sufficiency (≥ 75 nmol/L). There were 264 (17.4%) women diagnosed with GDM. There was not, however, an association between serum 25(OH)D in early pregnancy and GDM. Interestingly, women with more parity and high serum alkaline phosphatase levels had higher serum 25(OH)D levels. There was a possible positive association between serum 25(OH)D and pre-albumin, and a possible negative association between serum 25(OH)D, creatinine, and thrombin time. This study did not find an association between serum 25(OH)D and bone density. CONCLUSIONS: There were no associations between maternal serum 25(OH)D concentration in early pregnancy and the risk of GDM or bone density. There were, however, correlations between serum 25(OH)D and parity, seasoning at sampling, serum alkaline phosphatase, creatinine, pre-albumin, and coagulation factor thrombin time, which need further study to explain their pathophysiology and clinical significance. BioMed Central 2022-05-11 /pmc/articles/PMC9097231/ /pubmed/35545756 http://dx.doi.org/10.1186/s12884-022-04725-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Luo, Caihong Li, Zhiju Lu, Yunya Wei, Fang Suo, Dongmei Lan, Shiyan Ren, Zhengyuan Jiang, Runchang Huang, Fang Chen, Aiyue Jiang, Liejun Huang, Huayi Guo, Xiaoling Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title | Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title_full | Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title_fullStr | Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title_full_unstemmed | Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title_short | Association of serum vitamin D status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
title_sort | association of serum vitamin d status with gestational diabetes mellitus and other laboratory parameters in early pregnant women |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097231/ https://www.ncbi.nlm.nih.gov/pubmed/35545756 http://dx.doi.org/10.1186/s12884-022-04725-9 |
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