GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma

BACKGROUND: The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GABPA in clear cell renal cell carcinoma (ccRCC) is unclear. In addition, ccRCC is...

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Detalles Bibliográficos
Autores principales: Fang, Zhiqing, Zhang, Ning, Yuan, Xiaotian, Xing, Xiangling, Li, Xiaofeng, Qin, Xin, Liu, Zhengfang, Neo, Shiyong, Liu, Cheng, Kong, Feng, Björkholm, Magnus, Fan, Yidong, Xu, Dawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097325/
https://www.ncbi.nlm.nih.gov/pubmed/35549739
http://dx.doi.org/10.1186/s13046-022-02382-6

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