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Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust
BACKGROUND: There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors. RESULTS: In...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097390/ https://www.ncbi.nlm.nih.gov/pubmed/35551612 http://dx.doi.org/10.1186/s12951-022-01419-4 |
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author | Son, Taewoong Cho, Youn-Joo Lee, Hyunseung Cho, Mi Young Goh, Byeongwoo Kim, Hyun Min Hoa, Phan Thi Ngoc Cho, Sun-Hee Park, Young-Jun Park, Hye Sun Hong, Kwan Soo |
author_facet | Son, Taewoong Cho, Youn-Joo Lee, Hyunseung Cho, Mi Young Goh, Byeongwoo Kim, Hyun Min Hoa, Phan Thi Ngoc Cho, Sun-Hee Park, Young-Jun Park, Hye Sun Hong, Kwan Soo |
author_sort | Son, Taewoong |
collection | PubMed |
description | BACKGROUND: There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors. RESULTS: In this study, we focused on the difference in the biodistribution of fine dust according to the size distribution of particulate matter after inhalation into the body to predict its impact on human health. We synthesized Cy7-doped silica particulate matters (CSPMs) having different particle sizes and employed them as model fine dust, and studied their whole-body in vivo biodistribution in BALB/c nude mice. Image-tracking and quantitative and qualitative analyses were performed on the ex vivo organs and tissues. Additionally, flow cytometric analysis of single cells isolated from the lungs was performed. Smaller particles with a diameter of less than 100 nm (CSPM0.1) were observed to be removed relatively rapidly from the lungs upon initial inhalation. However, they were confirmed to accumulate continuously over 4 weeks of observation. In particular, smaller particles were found to spread rapidly to other organs during the early stages of inhalation. CONCLUSIONS: The results show in vivo behavioral differences that arisen from particle size through mouse experimental model. Although these are far from the human inhalation studies, it provides information that can help predict the effect of fine dust on human health. This study might provide with insights on association between CSPM0.1 accumulation in several organs including the lungs and adverse effect to underlying diseases in the organs. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01419-4. |
format | Online Article Text |
id | pubmed-9097390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90973902022-05-13 Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust Son, Taewoong Cho, Youn-Joo Lee, Hyunseung Cho, Mi Young Goh, Byeongwoo Kim, Hyun Min Hoa, Phan Thi Ngoc Cho, Sun-Hee Park, Young-Jun Park, Hye Sun Hong, Kwan Soo J Nanobiotechnology Research BACKGROUND: There has been growing concern regarding the impact of air pollution, especially fine dust, on human health. However, it is difficult to estimate the toxicity of fine dust on the human body because of its diverse effects depending on the composition and environmental factors. RESULTS: In this study, we focused on the difference in the biodistribution of fine dust according to the size distribution of particulate matter after inhalation into the body to predict its impact on human health. We synthesized Cy7-doped silica particulate matters (CSPMs) having different particle sizes and employed them as model fine dust, and studied their whole-body in vivo biodistribution in BALB/c nude mice. Image-tracking and quantitative and qualitative analyses were performed on the ex vivo organs and tissues. Additionally, flow cytometric analysis of single cells isolated from the lungs was performed. Smaller particles with a diameter of less than 100 nm (CSPM0.1) were observed to be removed relatively rapidly from the lungs upon initial inhalation. However, they were confirmed to accumulate continuously over 4 weeks of observation. In particular, smaller particles were found to spread rapidly to other organs during the early stages of inhalation. CONCLUSIONS: The results show in vivo behavioral differences that arisen from particle size through mouse experimental model. Although these are far from the human inhalation studies, it provides information that can help predict the effect of fine dust on human health. This study might provide with insights on association between CSPM0.1 accumulation in several organs including the lungs and adverse effect to underlying diseases in the organs. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12951-022-01419-4. BioMed Central 2022-05-12 /pmc/articles/PMC9097390/ /pubmed/35551612 http://dx.doi.org/10.1186/s12951-022-01419-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Son, Taewoong Cho, Youn-Joo Lee, Hyunseung Cho, Mi Young Goh, Byeongwoo Kim, Hyun Min Hoa, Phan Thi Ngoc Cho, Sun-Hee Park, Young-Jun Park, Hye Sun Hong, Kwan Soo Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title | Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title_full | Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title_fullStr | Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title_full_unstemmed | Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title_short | Monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
title_sort | monitoring in vivo behavior of size-dependent fluorescent particles as a model fine dust |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097390/ https://www.ncbi.nlm.nih.gov/pubmed/35551612 http://dx.doi.org/10.1186/s12951-022-01419-4 |
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