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Regulatory role of short-chain fatty acids in inflammatory bowel disease
Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosis of the gut microbiota (GM), causing a decrease in prebiotic levels and an increase in har...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097439/ https://www.ncbi.nlm.nih.gov/pubmed/35546404 http://dx.doi.org/10.1186/s12964-022-00869-5 |
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author | Zhang, Zhilin Zhang, Huan Chen, Tian Shi, Lin Wang, Daorong Tang, Dong |
author_facet | Zhang, Zhilin Zhang, Huan Chen, Tian Shi, Lin Wang, Daorong Tang, Dong |
author_sort | Zhang, Zhilin |
collection | PubMed |
description | Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosis of the gut microbiota (GM), causing a decrease in prebiotic levels and an increase in harmful metabolite levels. This leads to persistent immune response and inflammation in the intestine, greatly impairing the physiological function of the gastrointestinal tract. Short-chain fatty acids (SCFAs) are produced by probiotic gut bacteria from a fiber-rich diet that cannot be digested directly. SCFAs with significant anti-inflammatory functions regulate immune function and prevent an excessive immune response, thereby delaying the clinical progression of IBD. In this review, we summarize the generation of SCFAs and their potential therapeutic effects on IBD. Furthermore, we suggest that SCFAs may modulate innate immune recognition and cytokine production to intervene in the progression of IBD. Additional randomized controlled trials and prospective cohort studies should also investigate the clinical impact of SCFA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00869-5. |
format | Online Article Text |
id | pubmed-9097439 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-90974392022-05-13 Regulatory role of short-chain fatty acids in inflammatory bowel disease Zhang, Zhilin Zhang, Huan Chen, Tian Shi, Lin Wang, Daorong Tang, Dong Cell Commun Signal Review Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosis of the gut microbiota (GM), causing a decrease in prebiotic levels and an increase in harmful metabolite levels. This leads to persistent immune response and inflammation in the intestine, greatly impairing the physiological function of the gastrointestinal tract. Short-chain fatty acids (SCFAs) are produced by probiotic gut bacteria from a fiber-rich diet that cannot be digested directly. SCFAs with significant anti-inflammatory functions regulate immune function and prevent an excessive immune response, thereby delaying the clinical progression of IBD. In this review, we summarize the generation of SCFAs and their potential therapeutic effects on IBD. Furthermore, we suggest that SCFAs may modulate innate immune recognition and cytokine production to intervene in the progression of IBD. Additional randomized controlled trials and prospective cohort studies should also investigate the clinical impact of SCFA. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12964-022-00869-5. BioMed Central 2022-05-11 /pmc/articles/PMC9097439/ /pubmed/35546404 http://dx.doi.org/10.1186/s12964-022-00869-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Zhang, Zhilin Zhang, Huan Chen, Tian Shi, Lin Wang, Daorong Tang, Dong Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title | Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title_full | Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title_fullStr | Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title_full_unstemmed | Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title_short | Regulatory role of short-chain fatty acids in inflammatory bowel disease |
title_sort | regulatory role of short-chain fatty acids in inflammatory bowel disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097439/ https://www.ncbi.nlm.nih.gov/pubmed/35546404 http://dx.doi.org/10.1186/s12964-022-00869-5 |
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