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METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer
The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC. Functionally, we verified that METTL3 promoted tumor cell proliferation and angiogene...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097454/ https://www.ncbi.nlm.nih.gov/pubmed/35574388 http://dx.doi.org/10.3389/fonc.2022.861807 |
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author | Wang, Nuofan Huo, Xinying Zhang, Baoguo Chen, Xiaoxiang Zhao, Shuli Shi, Xuesong Xu, Hao Wei, Xiaowei |
author_facet | Wang, Nuofan Huo, Xinying Zhang, Baoguo Chen, Xiaoxiang Zhao, Shuli Shi, Xuesong Xu, Hao Wei, Xiaowei |
author_sort | Wang, Nuofan |
collection | PubMed |
description | The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC. Functionally, we verified that METTL3 promoted tumor cell proliferation and angiogenesis through a series of phenotypic experiments. Subsequently, ADAMTS9 was identified as the downstream effector of METTL3 in GC, which could be degraded by the YTHDF2-dependent pathway. Finally, the data suggested that METTL3 might facilitate GC progression through the ADAMTS9-mediated PI3K/AKT pathway. Our study unveiled the fundamental mechanisms of METTL3 in GC progression. The clinical value of METTL3 in GC deserves further exploration. |
format | Online Article Text |
id | pubmed-9097454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-90974542022-05-13 METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer Wang, Nuofan Huo, Xinying Zhang, Baoguo Chen, Xiaoxiang Zhao, Shuli Shi, Xuesong Xu, Hao Wei, Xiaowei Front Oncol Oncology The role of methyltransferase-like 3 (METTL3), which participates in catalyzing N-methyladenosine (m6A) RNA modification, in gastric cancer (GC) is unclear. Here, we found that METTL3 was overexpressed in human GC. Functionally, we verified that METTL3 promoted tumor cell proliferation and angiogenesis through a series of phenotypic experiments. Subsequently, ADAMTS9 was identified as the downstream effector of METTL3 in GC, which could be degraded by the YTHDF2-dependent pathway. Finally, the data suggested that METTL3 might facilitate GC progression through the ADAMTS9-mediated PI3K/AKT pathway. Our study unveiled the fundamental mechanisms of METTL3 in GC progression. The clinical value of METTL3 in GC deserves further exploration. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9097454/ /pubmed/35574388 http://dx.doi.org/10.3389/fonc.2022.861807 Text en Copyright © 2022 Wang, Huo, Zhang, Chen, Zhao, Shi, Xu and Wei https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Wang, Nuofan Huo, Xinying Zhang, Baoguo Chen, Xiaoxiang Zhao, Shuli Shi, Xuesong Xu, Hao Wei, Xiaowei METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title | METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title_full | METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title_fullStr | METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title_full_unstemmed | METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title_short | METTL3-Mediated ADAMTS9 Suppression Facilitates Angiogenesis and Carcinogenesis in Gastric Cancer |
title_sort | mettl3-mediated adamts9 suppression facilitates angiogenesis and carcinogenesis in gastric cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097454/ https://www.ncbi.nlm.nih.gov/pubmed/35574388 http://dx.doi.org/10.3389/fonc.2022.861807 |
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