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Hepatic decompensation is accelerated in patients with cirrhosis and alpha-1 antitrypsin Pi∗MZ genotype

BACKGROUND & AIMS: Alpha-1 antitrypsin deficiency is caused by mutations in SERPINA1, most commonly homozygosity for the Pi∗Z variant, and can present as liver disease. While heterozygosity for Pi∗Z (Pi∗MZ) is linked to increased risk of cirrhosis, whether the Pi∗MZ genotype is associated with a...

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Detalles Bibliográficos
Autores principales:	Chen, Vincent L., Burkholder, Daniel A., Moran, Isabel J., DiBattista, Jacob V., Miller, Matthew J., Chen, Yanhua, Du, Xiaomeng, Oliveri, Antonino, Cushing, Kelly C., Lok, Anna S., Speliotes, Elizabeth K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097455/ https://www.ncbi.nlm.nih.gov/pubmed/35571533 http://dx.doi.org/10.1016/j.jhepr.2022.100483

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