A kinetic model of phospholipase C-γ1 linking structure-based insights to dynamics of enzyme autoinhibition and activation

Phospholipase C-γ1 (PLC-γ1) is a receptor-proximal enzyme that promotes signal transduction through PKC in mammalian cells. Because of the complexity of PLC-γ1 regulation, a two-state (inactive/active) model does not account for the intricacy of activation and inactivation steps at the plasma membra...

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Detalles Bibliográficos
Autores principales: Nosbisch, Jamie L., Bear, James E., Haugh, Jason M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097458/
https://www.ncbi.nlm.nih.gov/pubmed/35367415
http://dx.doi.org/10.1016/j.jbc.2022.101886

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097458/
https://www.ncbi.nlm.nih.gov/pubmed/35367415
http://dx.doi.org/10.1016/j.jbc.2022.101886

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