Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase γ Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode

[Image: see text] Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) are emerging as attractive therapeutic targets in diseases, such as cancer, immunological disorders, and neurodegeneration, owing to their central role in regulating cell signaling pathways that are either dysfunctional or can be...

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Detalles Bibliográficos
Autores principales: Boffey, Helen K., Rooney, Timothy P. C., Willems, Henriette M. G., Edwards, Simon, Green, Christopher, Howard, Tina, Ogg, Derek, Romero, Tamara, Scott, Duncan E., Winpenny, David, Duce, James, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097471/
https://www.ncbi.nlm.nih.gov/pubmed/35148092
http://dx.doi.org/10.1021/acs.jmedchem.1c01819

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