Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier

The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps...

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Autores principales: Che, Qingya, Luo, Tingting, Shi, Junhua, He, Yihuai, Xu, De-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097517/
https://www.ncbi.nlm.nih.gov/pubmed/35573786
http://dx.doi.org/10.3389/fcimb.2022.863779
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author Che, Qingya
Luo, Tingting
Shi, Junhua
He, Yihuai
Xu, De-Lin
author_facet Che, Qingya
Luo, Tingting
Shi, Junhua
He, Yihuai
Xu, De-Lin
author_sort Che, Qingya
collection PubMed
description The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM.
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spelling pubmed-90975172022-05-13 Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier Che, Qingya Luo, Tingting Shi, Junhua He, Yihuai Xu, De-Lin Front Cell Infect Microbiol Cellular and Infection Microbiology The effect of a drug on the intestinal flora and the intestinal barrier is an important evaluation index for drug safety and efficacy. Chemical synthetic drugs are widely used due to their advantages of fast efficacy and low doses, but they are prone to cause drug resistance and inhibit proton pumps, which may harm intestinal health. Traditional Chinese medicine (TCM) has been applied clinically for thousands of years, and how TCMs regulate intestinal health to achieve their effects of disease treatment has become a hot research topic that needs to be resolved. This paper reviews the recent research on the effects of TCMs on intestinal microorganisms and the intestinal mucosal barrier after entering the intestine, discusses the interaction mechanisms between TCMs and intestinal flora, and details the repair effect of TCMs on the intestinal mucosal barrier to provide a reference for the development, utilization, and modernization of TCM. Frontiers Media S.A. 2022-04-28 /pmc/articles/PMC9097517/ /pubmed/35573786 http://dx.doi.org/10.3389/fcimb.2022.863779 Text en Copyright © 2022 Che, Luo, Shi, He and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Che, Qingya
Luo, Tingting
Shi, Junhua
He, Yihuai
Xu, De-Lin
Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title_full Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title_fullStr Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title_full_unstemmed Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title_short Mechanisms by Which Traditional Chinese Medicines Influence the Intestinal Flora and Intestinal Barrier
title_sort mechanisms by which traditional chinese medicines influence the intestinal flora and intestinal barrier
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097517/
https://www.ncbi.nlm.nih.gov/pubmed/35573786
http://dx.doi.org/10.3389/fcimb.2022.863779
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