Too close for comfort? Endomembranes promote missegregation by enclosing lost chromosomes

Correct segregation of chromosomes during mitosis is essential to prevent aneuploidy. In this issue, Ferrandiz et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202203021) show that endomembranes can promote chromosome missegregation by “ensheathing” misaligned chromosomes, preventing their in...

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Detalles Bibliográficos
Autores principales: Donker, Lisa, Godinho, Susana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Spotlight
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097545/
https://www.ncbi.nlm.nih.gov/pubmed/35536317
http://dx.doi.org/10.1083/jcb.202204114
Descripción
Sumario:Correct segregation of chromosomes during mitosis is essential to prevent aneuploidy. In this issue, Ferrandiz et al. (2022. J. Cell Biol. https://doi.org/10.1083/jcb.202203021) show that endomembranes can promote chromosome missegregation by “ensheathing” misaligned chromosomes, preventing their integration into the metaphase plate. Their findings point toward endomembranes as a potential risk factor for aneuploidy.

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