Cargando…

N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel

A copolymer termed HASL produced from monomeric units of 2-acrylamido-2-methyl-1-(5-methylhydantoinyl)propane (HA) and of 3-(trimethoxysilyl)propyl methacrylate (SL) has been coated onto stainless steel and Inconel™ substrates, which upon halogenation with either aqueous oxidative chlorine or bromin...

Descripción completa

Detalles Bibliográficos
Autores principales: Demir, Buket, Taylor, Alicia, Broughton, R.M., Huang, T.-S., Bozack, M.J., Worley, S.D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097693/
https://www.ncbi.nlm.nih.gov/pubmed/35572468
http://dx.doi.org/10.1016/j.bioflm.2022.100076
_version_ 1784706231676436480
author Demir, Buket
Taylor, Alicia
Broughton, R.M.
Huang, T.-S.
Bozack, M.J.
Worley, S.D.
author_facet Demir, Buket
Taylor, Alicia
Broughton, R.M.
Huang, T.-S.
Bozack, M.J.
Worley, S.D.
author_sort Demir, Buket
collection PubMed
description A copolymer termed HASL produced from monomeric units of 2-acrylamido-2-methyl-1-(5-methylhydantoinyl)propane (HA) and of 3-(trimethoxysilyl)propyl methacrylate (SL) has been coated onto stainless steel and Inconel™ substrates, which upon halogenation with either aqueous oxidative chlorine or bromine, became antimicrobial. It has been demonstrated that the halogenated stainless steel and Inconel™ substrates were effective in producing 6 to 7 log inactivations of Staphylococcus aureus and Escherichia coli O157:H7 within about 10 min, and in prevention of Pseudomonas aeruginosa biofilm formation over a period of at least 72 h on the stainless steel substrates. Upon loss of halogen, the HASL coating could be re-charged with aqueous halogen. The HASL coating was easily applied to the substrates via a simple dip-coating method and was reasonably stable to contact with water. Both chlorinated substrates could be loaded with at least 6 × 10(16) oxidative Cl atoms per cm(2) and maintained a loading of greater than 1 × 10(16) chlorine atoms per cm(2) for a period of 3–7 days while agitated in aqueous solution. After loss of chlorine to a level below 1 × 10(16) atoms per cm(2), the substrates could be recharged to the 6 × 10(16) Cl atoms per cm(2) level for at least 5 times over a 28 day period. The new antimicrobial coating technology has potential for use in a variety of important applications, particularly for water treatment and storage on spacecraft.
format Online
Article
Text
id pubmed-9097693
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-90976932022-05-13 N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel Demir, Buket Taylor, Alicia Broughton, R.M. Huang, T.-S. Bozack, M.J. Worley, S.D. Biofilm Article A copolymer termed HASL produced from monomeric units of 2-acrylamido-2-methyl-1-(5-methylhydantoinyl)propane (HA) and of 3-(trimethoxysilyl)propyl methacrylate (SL) has been coated onto stainless steel and Inconel™ substrates, which upon halogenation with either aqueous oxidative chlorine or bromine, became antimicrobial. It has been demonstrated that the halogenated stainless steel and Inconel™ substrates were effective in producing 6 to 7 log inactivations of Staphylococcus aureus and Escherichia coli O157:H7 within about 10 min, and in prevention of Pseudomonas aeruginosa biofilm formation over a period of at least 72 h on the stainless steel substrates. Upon loss of halogen, the HASL coating could be re-charged with aqueous halogen. The HASL coating was easily applied to the substrates via a simple dip-coating method and was reasonably stable to contact with water. Both chlorinated substrates could be loaded with at least 6 × 10(16) oxidative Cl atoms per cm(2) and maintained a loading of greater than 1 × 10(16) chlorine atoms per cm(2) for a period of 3–7 days while agitated in aqueous solution. After loss of chlorine to a level below 1 × 10(16) atoms per cm(2), the substrates could be recharged to the 6 × 10(16) Cl atoms per cm(2) level for at least 5 times over a 28 day period. The new antimicrobial coating technology has potential for use in a variety of important applications, particularly for water treatment and storage on spacecraft. Elsevier 2022-05-02 /pmc/articles/PMC9097693/ /pubmed/35572468 http://dx.doi.org/10.1016/j.bioflm.2022.100076 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Demir, Buket
Taylor, Alicia
Broughton, R.M.
Huang, T.-S.
Bozack, M.J.
Worley, S.D.
N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title_full N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title_fullStr N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title_full_unstemmed N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title_short N-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
title_sort n-halamine surface coating for mitigation of biofilm and microbial contamination in water systems for space travel
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097693/
https://www.ncbi.nlm.nih.gov/pubmed/35572468
http://dx.doi.org/10.1016/j.bioflm.2022.100076
work_keys_str_mv AT demirbuket nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel
AT tayloralicia nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel
AT broughtonrm nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel
AT huangts nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel
AT bozackmj nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel
AT worleysd nhalaminesurfacecoatingformitigationofbiofilmandmicrobialcontaminationinwatersystemsforspacetravel