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High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice

Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher intratumor dihydrotestosterone (DHT) concentration than th...

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Detalles Bibliográficos
Autores principales:	Huhtaniemi, Riikka, Sipilä, Petra, Junnila, Arttu, Oksala, Riikka, Knuuttila, Matias, Mehmood, Arfa, Aho, Eija, Laajala, Teemu D., Aittokallio, Tero, Laiho, Asta, Elo, Laura, Ohlsson, Claes, Thulin, Malin Hagberg, Kallio, Pekka, Mäkelä, Sari, Mustonen, Mika V.J., Poutanen, Matti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097697/ https://www.ncbi.nlm.nih.gov/pubmed/35573198 http://dx.doi.org/10.1016/j.isci.2022.104287

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