CCK2 receptors in chronic pain

The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In this mini-review, we discuss what is known about CCK...

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Detalles Bibliográficos
Autores principales: LaVigne, Justin E., Alles, Sascha R.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Mini Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097710/
https://www.ncbi.nlm.nih.gov/pubmed/35571964
http://dx.doi.org/10.1016/j.ynpai.2022.100092
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author LaVigne, Justin E.
Alles, Sascha R.A.
author_facet LaVigne, Justin E.
Alles, Sascha R.A.
author_sort LaVigne, Justin E.
collection PubMed
description The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In this mini-review, we discuss what is known about CCK2R in peripheral and central circuits under naïve physiological conditions and under conditions of chronic pain, the interactions of CCK2Rs with opioids and briefly, recent efforts to develop new treatments targeting CCK2R for chronic pain.
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spelling pubmed-90977102022-05-13 CCK2 receptors in chronic pain LaVigne, Justin E. Alles, Sascha R.A. Neurobiol Pain Mini Review The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a historic target for pain management that has shown limited success. However, new approaches to target CCK2R have incited fresh enthusiasm for this target. In this mini-review, we discuss what is known about CCK2R in peripheral and central circuits under naïve physiological conditions and under conditions of chronic pain, the interactions of CCK2Rs with opioids and briefly, recent efforts to develop new treatments targeting CCK2R for chronic pain. Elsevier 2022-05-05 /pmc/articles/PMC9097710/ /pubmed/35571964 http://dx.doi.org/10.1016/j.ynpai.2022.100092 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Mini Review
LaVigne, Justin E.
Alles, Sascha R.A.
CCK2 receptors in chronic pain
title CCK2 receptors in chronic pain
title_full CCK2 receptors in chronic pain
title_fullStr CCK2 receptors in chronic pain
title_full_unstemmed CCK2 receptors in chronic pain
title_short CCK2 receptors in chronic pain
title_sort cck2 receptors in chronic pain
topic Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097710/
https://www.ncbi.nlm.nih.gov/pubmed/35571964
http://dx.doi.org/10.1016/j.ynpai.2022.100092
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