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Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis

Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-li...

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Autores principales: Jimenez-Martin, Jon, Las Heras, Kevin, Etxabide, Alaitz, Uranga, Jone, de la Caba, Koro, Guerrero, Pedro, Igartua, Manoli, Santos-Vizcaino, Edorta, Hernandez, Rosa Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097720/
https://www.ncbi.nlm.nih.gov/pubmed/35572855
http://dx.doi.org/10.1016/j.mtbio.2022.100273
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author Jimenez-Martin, Jon
Las Heras, Kevin
Etxabide, Alaitz
Uranga, Jone
de la Caba, Koro
Guerrero, Pedro
Igartua, Manoli
Santos-Vizcaino, Edorta
Hernandez, Rosa Maria
author_facet Jimenez-Martin, Jon
Las Heras, Kevin
Etxabide, Alaitz
Uranga, Jone
de la Caba, Koro
Guerrero, Pedro
Igartua, Manoli
Santos-Vizcaino, Edorta
Hernandez, Rosa Maria
author_sort Jimenez-Martin, Jon
collection PubMed
description Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-like scaffold (SP–CH) produced from natural by-products of the food industry — soy protein and β-chitin — can be employed as a nasal pack for the treatment of epistaxis. To evaluate the potential of our material as a nasal pack, it was compared with two of the most commonly used nasal packs in the clinic: a basic gauze and the gold standard Merocel®. Our SP-CH presented great physicochemical and mechanical properties, lost weight in aqueous medium, and could even partially degrade when incubated in blood. It was shown to be both biocompatible and hemocompatible in vitro, clearing up any doubt about its safety. It showed increased blood clotting capacity in vitro, as well as increased capacity to bind both red blood cells and platelets, compared to the standard gauze and Merocel®. Finally, a rat-tail amputation model revealed that our SP-CH could even reduce bleeding time in vivo. This work, carried out from a circular economy approach, demonstrates that a green strategy can be followed to manufacture nasal packs using valorized by-products of the food industry, with equal or even better hemostatic properties than the gold standard in the clinic.
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spelling pubmed-90977202022-05-13 Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis Jimenez-Martin, Jon Las Heras, Kevin Etxabide, Alaitz Uranga, Jone de la Caba, Koro Guerrero, Pedro Igartua, Manoli Santos-Vizcaino, Edorta Hernandez, Rosa Maria Mater Today Bio Full Length Article Epistaxis is one of the most common otorhinolaryngology emergencies worldwide. Although there are currently several treatments available, they present several disadvantages. This, in addition to the increasing social need of being environmentally respectful, led us to investigate whether a sponge-like scaffold (SP–CH) produced from natural by-products of the food industry — soy protein and β-chitin — can be employed as a nasal pack for the treatment of epistaxis. To evaluate the potential of our material as a nasal pack, it was compared with two of the most commonly used nasal packs in the clinic: a basic gauze and the gold standard Merocel®. Our SP-CH presented great physicochemical and mechanical properties, lost weight in aqueous medium, and could even partially degrade when incubated in blood. It was shown to be both biocompatible and hemocompatible in vitro, clearing up any doubt about its safety. It showed increased blood clotting capacity in vitro, as well as increased capacity to bind both red blood cells and platelets, compared to the standard gauze and Merocel®. Finally, a rat-tail amputation model revealed that our SP-CH could even reduce bleeding time in vivo. This work, carried out from a circular economy approach, demonstrates that a green strategy can be followed to manufacture nasal packs using valorized by-products of the food industry, with equal or even better hemostatic properties than the gold standard in the clinic. Elsevier 2022-04-30 /pmc/articles/PMC9097720/ /pubmed/35572855 http://dx.doi.org/10.1016/j.mtbio.2022.100273 Text en © 2022 The Authors https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Full Length Article
Jimenez-Martin, Jon
Las Heras, Kevin
Etxabide, Alaitz
Uranga, Jone
de la Caba, Koro
Guerrero, Pedro
Igartua, Manoli
Santos-Vizcaino, Edorta
Hernandez, Rosa Maria
Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title_full Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title_fullStr Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title_full_unstemmed Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title_short Green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
title_sort green hemostatic sponge-like scaffold composed of soy protein and chitin for the treatment of epistaxis
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097720/
https://www.ncbi.nlm.nih.gov/pubmed/35572855
http://dx.doi.org/10.1016/j.mtbio.2022.100273
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