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KL1 Domain of Longevity Factor Klotho Mimics the Metabolome of Cognitive Stimulation and Enhances Cognition in Young and Aging Mice

Cognitive deficits are a major biomedical challenge—and engagement of the brain in stimulating tasks improves cognition in aged individuals (Wilson et al., 2002; Gates et al., 2011) and rodents (Aidil-Carvalho et al., 2017), through unknown mechanisms. Whether cognitive stimulation alters specific m...

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Detalles Bibliográficos
Autores principales: Gupta, Shweta, Moreno, Arturo J., Wang, Dan, Leon, Julio, Chen, Chen, Hahn, Oliver, Poon, Yan, Greenberg, Kenneth, David, Nathaniel, Wyss-Coray, Tony, Raftery, Daniel, Promislow, Daniel E.L., Dubal, Dena B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097772/
https://www.ncbi.nlm.nih.gov/pubmed/35428698
http://dx.doi.org/10.1523/JNEUROSCI.2458-21.2022