Cargando…

FGF21 alleviates pulmonary hypertension by inhibiting mTORC1/EIF4EBP1 pathway via H19

Long non‐coding RNAs (lncRNAs) play a significant role in pulmonary hypertension (PH). Our preliminary data showed that hypoxia‐induced PH is attenuated by fibroblast growth factor 21 (FGF21) administration. Therefore, we further investigated the regulatory role of long non‐coding RNAs in PH treated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xiuchun, Zhang, Yaxin, Su, Lihuang, Cai, Luqiong, Zhang, Chi, Zhang, Jianhao, Sun, Junwei, Chai, Mengyu, Cai, Mengsi, Wu, Qian, Yan, Xiaoqing, Wang, Liangxing, Huang, Xiaoying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097832/ https://www.ncbi.nlm.nih.gov/pubmed/35437883 http://dx.doi.org/10.1111/jcmm.17318

Ejemplares similares

FGF21 attenuates pulmonary arterial hypertension via downregulation of miR‐130, which targets PPARγ
por: Wang, Meibin, et al.
Publicado: (2022)

FGF21 attenuates hypoxia-induced dysfunction and inflammation in HPAECs via the microRNA-27b-mediated PPARγ pathway
por: Yao, Dan, et al.
Publicado: (2021)

mTORC1 and CK2 coordinate ternary and eIF4F complex assembly
por: Gandin, Valentina, et al.
Publicado: (2016)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Integrated bioinformatic analysis reveals the underlying molecular mechanism of and potential drugs for pulmonary arterial hypertension
por: Dong, Haoru, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
por: Luo, Yan, et al.
Publicado: (2015)

Discordant regulation of eIF2 kinase GCN2 and mTORC1 during nutrient stress
por: Misra, Jagannath, et al.
Publicado: (2021)

Dietary protein and age-dependent female fertility: FGF21 trumps mTORC1
por: Rose, Adam J.
Publicado: (2019)

Bi-steric mTORC1 inhibitors induce apoptotic cell death in tumor models with hyperactivated mTORC1
por: Du, Heng, et al.
Publicado: (2023)

Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice
por: Zidek, Laura M, et al.
Publicado: (2015)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

The metabolic waste ammonium regulates mTORC2 and mTORC1 signaling
por: Merhi, Ahmad, et al.
Publicado: (2017)

Exosome Release Is Regulated by mTORC1
por: Zou, Wenchong, et al.
Publicado: (2018)

Functional Translatome Proteomics Reveal Converging and Dose-Dependent Regulation by mTORC1 and eIF2α
por: Klann, Kevin, et al.
Publicado: (2020)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Rapamycin-insensitive mTORC1 activity controls eIF4E:4E-BP1 binding
por: Livingstone, Mark, et al.
Publicado: (2012)

Defects in mTORC1 Network and mTORC1-STAT3 Pathway Crosstalk Contributes to Non-inflammatory Hepatocellular Carcinoma
por: Li, Ting, et al.
Publicado: (2020)

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation
por: Ding, Xiaolei, et al.
Publicado: (2016)

LPS Induces mTORC1 and mTORC2 Activation During Monocyte Adhesion
por: Ribeiro, Marcelle C., et al.
Publicado: (2018)

mTORC1 and mTORC2 differentially promote natural killer cell development
por: Yang, Chao, et al.
Publicado: (2018)

mTORC1 and mTORC2 are differentially engaged in the development of laser-induced CNV
por: Yang, Jin Young, et al.
Publicado: (2019)

Dopamine neuron morphology and output are differentially controlled by mTORC1 and mTORC2
por: Kosillo, Polina, et al.
Publicado: (2022)

Sin1–mTORC2 signaling drives glycolysis of developing thymocytes
por: Chi, Hongbo
Publicado: (2018)

A Nomogram Integrating Ferroptosis- and Immune-Related Biomarkers for Prediction of Overall Survival in Lung Adenocarcinoma
por: Chai, Mengyu, et al.
Publicado: (2021)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway
por: Wang, Zeng, et al.
Publicado: (2020)

Glutaminolysis feeds mTORC1
por: Durán, Raúl V., et al.
Publicado: (2012)

Regulation of adiposity by mTORC1
por: Magdalon, Juliana, et al.
Publicado: (2017)

Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs)
por: Rios-Fuller, Tiffany J., et al.
Publicado: (2020)

Regulation of mTORC1 by lysosomal calcium and calmodulin
por: Li, Ruo-Jing, et al.
Publicado: (2016)

mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
por: Yan, Bo, et al.
Publicado: (2016)

TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2
por: Zhang, Zhiyong, et al.
Publicado: (2019)

Borneol promotes apoptosis of Human Glioma Cells through regulating HIF-1a expression via mTORC1/eIF4E pathway: Erratum
por: Wang, Zeng, et al.
Publicado: (2022)

Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals
por: Tao, Huishan, et al.
Publicado: (2021)

Feedback Activation of SGK3 and AKT Contributes to Rapamycin Resistance by Reactivating mTORC1/4EBP1 Axis via TSC2 in Breast Cancer
por: Wang, Hongtao, et al.
Publicado: (2019)

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control
por: Gan, Wenjian, et al.
Publicado: (2020)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2
por: Wang, Weijie, et al.
Publicado: (2014)

Inhibition of mTORC1 Enhances the Translation of Chikungunya Proteins via the Activation of the MnK/eIF4E Pathway
por: Joubert, Pierre-Emmanuel, et al.
Publicado: (2015)

mTORC1 Prevents Preosteoblast Differentiation through the Notch Signaling Pathway
por: Huang, Bin, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_967ut04gklbekn3vcajled50gq