An engineered ACE2 decoy neutralizes the SARS-CoV-2 Omicron variant and confers protection against infection in vivo

The Omicron (B.1.1.529) SARS-CoV-2 variant contains an unusually high number of mutations in the spike protein, raising concerns of escape from vaccines, convalescent serum and therapeutic drugs. Here we analyzed the degree to which Omicron pseudovirus evades neutralization by serum or therapeutic a...

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Detalles Bibliográficos
Autores principales: Ikemura, Nariko, Taminishi, Shunta, Inaba, Tohru, Arimori, Takao, Motooka, Daisuke, Katoh, Kazutaka, Kirita, Yuhei, Higuchi, Yusuke, Li, Songling, Suzuki, Tatsuya, Itoh, Yumi, Ozaki, Yuki, Nakamura, Shota, Matoba, Satoaki, Standley, Daron M, Okamoto, Toru, Takagi, Junichi, Hoshino, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097879/
https://www.ncbi.nlm.nih.gov/pubmed/35471044
http://dx.doi.org/10.1126/scitranslmed.abn7737

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