REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robust, and sustained therapeutic effects in patients w...

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Detalles Bibliográficos
Autores principales: Bifari, Francesco, Pappagallo, Marco, Bleavins, Michael, Traversa, Sergio, Folli, Franco, Manfredi, Paolo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097919/
https://www.ncbi.nlm.nih.gov/pubmed/35571103
http://dx.doi.org/10.3389/fphar.2022.863959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097919/
https://www.ncbi.nlm.nih.gov/pubmed/35571103
http://dx.doi.org/10.3389/fphar.2022.863959

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