Cargando…

REL-1017 (Esmethadone), A Novel NMDAR Blocker for the Treatment of MDD is Not Neurotoxic in Sprague-Dawley Rats

REL-1017 (esmethadone; dextromethadone; (S)-methadone) is the opioid-inactive dextro-isomer of the racemic mixture, (R, S)-methadone. REL-1017 acts as a low affinity, low potency N-methyl-D-aspartate receptor (NMDAR) channel blocker with rapid, robust, and sustained therapeutic effects in patients w...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bifari, Francesco, Pappagallo, Marco, Bleavins, Michael, Traversa, Sergio, Folli, Franco, Manfredi, Paolo L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9097919/ https://www.ncbi.nlm.nih.gov/pubmed/35571103 http://dx.doi.org/10.3389/fphar.2022.863959

Ejemplares similares

REL-1017 (esmethadone; d-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats
por: Henningfield, Jack, et al.
Publicado: (2022)

Esmethadone-HCl (REL-1017): a promising rapid antidepressant
por: Fava, Maurizio, et al.
Publicado: (2023)

Pharmacological Comparative Characterization of REL-1017 (Esmethadone-HCl) and Other NMDAR Channel Blockers in Human Heterodimeric N-Methyl-D-Aspartate Receptors
por: Bettini, Ezio, et al.
Publicado: (2022)

The N-Methyl-D-Aspartate Receptor Blocker REL-1017 (Esmethadone) Reduces Calcium Influx Induced by Glutamate, Quinolinic Acid, and Gentamicin
por: Bettini, Ezio, et al.
Publicado: (2022)

Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling
por: Stahl, Stephen M., et al.
Publicado: (2022)

REL-1017 (Esmethadone) Increases Circulating BDNF Levels in Healthy Subjects of a Phase 1 Clinical Study
por: De Martin, Sara, et al.
Publicado: (2021)

REL-1017 (Esmethadone) May Rapidly Reduce Dissociative Symptoms in Adults With Major Depressive Disorder Unresponsive to Standard Antidepressants: A Report of 2 Cases
por: Guidetti, Clotilde, et al.
Publicado: (2022)

The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users
por: Shram, Megan J., et al.
Publicado: (2023)

Developmental Neurotoxicity Study of Dietary Bisphenol A in Sprague-Dawley Rats
por: Stump, Donald G., et al.
Publicado: (2010)

Serum Acetyl Cholinesterase as a Biomarker of Arsenic Induced Neurotoxicity in Sprague-Dawley Rats
por: Patlolla, Anita K., et al.
Publicado: (2005)

Minocycline protects against acrylamide-induced neurotoxicity and testicular damage in Sprague-Dawley rats
por: Radad, Khaled, et al.
Publicado: (2020)

An evaluation of the effects of nonselective and cardioselective β-blockers on wound healing in Sprague Dawley rats
por: Raut, Sanket B., et al.
Publicado: (2012)

Sex-specific acute and chronic neurotoxicity of acute diisopropylfluorophosphate (DFP)-intoxication in juvenile Sprague-Dawley rats
por: González, Eduardo A., et al.
Publicado: (2021)

Ovarian neoplasia in the Sprague-Dawley rat.
por: Lewis, D J
Publicado: (1987)

Hematoxicity of Amodiaquine in Sprague-Dawley Rats
por: Saka, W. A., et al.
Publicado: (2012)

Keishibukuryogan is not carcinogenic in Sprague-Dawley rats
por: Kanitani, Masanao, et al.
Publicado: (2016)

Cutaneous Hybrid Cyst in a Sprague-Dawley Rat
por: Yasuno, Kyohei, et al.
Publicado: (2012)

Intratubular Spermatocytic Seminomas in 2 Sprague-Dawley Rats
por: Ishigami, Noriaki, et al.
Publicado: (2014)

Reproductive and Developmental Toxicity of Amitraz in Sprague-Dawley Rats
por: Lim, Jeong-Hyeon, et al.
Publicado: (2010)

Splenic Hemangiosarcoma in a Young Sprague-Dawley Rat
por: Shiraki, Katsuhisa, et al.
Publicado: (2012)

Subchronic Inhalation Toxicity of Trichloroacetonitrile on the Sprague Dawley Rats
por: Han, Jeong-Hee, et al.
Publicado: (2015)

Memory deficits in Sprague Dawley rats with spontaneous ventriculomegaly
por: Luna‐Munguia, Hiram, et al.
Publicado: (2020)

Solitary foot mass on a Sprague-Dawley rat
por: Rosenbaum, Matthew D, et al.
Publicado: (2010)

Reproductive effects of sulfoxaflor in male Sprague Dawley rats
por: Mohamed, Wafaa H., et al.
Publicado: (2022)

Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats
por: Colom-Rocha, Carles, et al.
Publicado: (2023)

Experimental evidence of the neurotoxic effect of monosodium glutamate in adult female Sprague Dawley rats: The potential protective role of Zingiber officinale Rosc. rhizomes
por: El-Hashash, Samah A., et al.
Publicado: (2023)

Dataset of acute oral toxicity and subacute neurotoxicity risk assessments of flavonoid-enriched fraction extracted from Oroxylum Indicum on Sprague Dawley rats
por: Othman, Farah Amna, et al.
Publicado: (2023)

Teratogenic and Embryocidal Effects of Zidovudine (AZT) in Sprague-Dawley Rats
por: Christmas, James T., et al.
Publicado: (1995)

Polychlorinated biphenyl induction of hepatocellular carcinoma in the Sprague-Dawley rat.
por: Norback, D H, et al.
Publicado: (1985)

Natural Occurrence of Neoplastic Lesions in Young Sprague-Dawley Rats
por: Ikezaki, Shinichiro, et al.
Publicado: (2011)

Comparative Hematoxicity of Fusirium Mycotoxin in Experimental Sprague-Dawley Rats
por: Chattopadhyay, Pronobesh, et al.
Publicado: (2013)

Biopersistence of silver nanoparticles in tissues from Sprague–Dawley rats
por: Lee, Ji Hyun, et al.
Publicado: (2013)

Toxicity Evaluation of Graphene Oxide in Kidneys of Sprague-Dawley Rats
por: Patlolla, Anita K., et al.
Publicado: (2016)

Leptin Influences Healing in the Sprague Dawley Rat Fracture Model
por: Liu, Pengcheng, et al.
Publicado: (2017)

Sprague Dawley rats: A model of successful heart aging
por: Capitanio, Daniele, et al.
Publicado: (2016)

A gene catalogue of the Sprague-Dawley rat gut metagenome
por: Pan, Hudan, et al.
Publicado: (2018)

Reference ranges for rotational thromboelastometry in male Sprague Dawley rats
por: Cruz, Mariana Vigiola, et al.
Publicado: (2017)

Pharmacokinetic data of synthetic cathinones in female Sprague-Dawley rats
por: Grecco, Gregory G., et al.
Publicado: (2018)

Aversion to Desflurane and Isoflurane in Sprague-Dawley Rats (Rattus norvegicus)
por: Frost, Katrina, et al.
Publicado: (2020)

Effect of shell as natural testosterone boosters in Sprague Dawley rats
por: Astuti, Pudji, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_pgqhpb4op2gl3jgkch2fem9udv